INT317149

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0
Pain Relevance 0.25

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signal transduction (Uts2r) plasma membrane (Uts2r) signal transducer activity (Uts2r)
Anatomy Link Frequency
dendrites 2
neurons 2
Uts2r (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 42 99.54 Very High Very High Very High
Hippocampus 14 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 119 50.00 Quite Low
Repression 7 9.68 Low Low
Hypersensitivity 28 5.00 Very Low Very Low Very Low
Death 21 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 14 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low
Dementia 7 5.00 Very Low Very Low Very Low
Anxiety Disorder 7 5.00 Very Low Very Low Very Low
Frailty 7 5.00 Very Low Very Low Very Low
Depression 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result suggests that Htt co-localizes with BDNF-3'UTR mRNA in dendrites.
Localization (localizes) of UTR in dendrites
1) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.04
Using live-cell imaging, we also examined the localization of transfected RFP-Htt480-17Q and BDNF-3'UTR short mRNA (detected by NLS-MS2-Venus) in cortical neurons (Fig. 2).
Spec (examined) Localization (localization) of UTR in neurons associated with imagery
2) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.05
Staining for endogenous Htt showed significant co-localization with all three BDNF-3'UTR reporters (detected by NLS-MS2-Venus) in cortical dendrites (Fig. 1d-f).
Localization (localization) of UTR in dendrites
3) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.03
Quantitative analysis of one projection from the image stack shows 35.7% of short 3'UTR, 38.8% of long 3'UTR and 31.5% of full-length 3'UTR to co-localize with endogenous Htt.
Localization (localize) of UTR
4) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.04
Quantitative analysis of one projection from the image stack shows 35.7% of short 3'UTR, 38.8% of long 3'UTR and 31.5% of full-length 3'UTR to co-localize with endogenous Htt.
Localization (localize) of UTR
5) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.04
We have also demonstrated that the 3'UTR of BDNF mRNA and Htt co-localize and co-traffic in cortical neurons.
Localization (localize) of UTR in neurons
6) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
Quantitative analysis of one projection from the image stack shows 35.7% of short 3'UTR, 38.8% of long 3'UTR and 31.5% of full-length 3'UTR to co-localize with endogenous Htt.
Localization (localize) of UTR
7) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.04

General Comments

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