INT317162

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.20
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Bdnf, Htt) Golgi apparatus (Htt) endoplasmic reticulum (Htt)
mitochondrion organization (Htt) embryo development (Htt) protein complex (Htt)
Anatomy Link Frequency
neurons 2
neuronal 1
soma 1
Bdnf (Rattus norvegicus)
Htt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 30 94.00 High High
depression 5 60.08 Quite High
Hippocampus 10 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 85 75.00 Quite High
Depression 5 60.08 Quite High
Anxiety Disorder 5 33.76 Quite Low
Neurodegenerative Disease 10 30.64 Quite Low
Death 15 29.12 Quite Low
Repression 5 20.80 Low Low
Frailty 5 19.36 Low Low
Hypersensitivity 20 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Dementia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine further the association of Htt with BDNF mRNA in neurons, we used the MS2-fluorescent reporter RNA localization system to test if endogenous Htt can be detected in RNA granules that contain BDNF-3'UTR mRNA (Fig. 1c).
BDNF Spec (examine) Binding (association) of Htt in neurons
1) Confidence 0.51 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
The discovery that BDNF mRNA is associated with Ago2 and Htt suggests a new mechanism for BDNF gene expression mediated through mRNA processing in neuronal granules.
BDNF Binding (associated) of Htt in neuronal
2) Confidence 0.51 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.06 Pain Relevance 0.03
Htt was found to co-traffic with BDNF 3'UTR short mRNA in granules moving from the periphery towards the cell soma, indicating that Htt may be involved in retrograde dendritic trafficking of BDNF mRNA through its 3'UTR (Fig. 2 and additional file 1).


BDNF 3 Binding (found) of Htt in soma
3) Confidence 0.39 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.05
Therefore, it is difficult to know whether the observed small percentage of BDNF mRNA co-localizing with Ago2 and Htt suggests involvement of a labile component.
BDNF Binding (localizing) of Htt
4) Confidence 0.38 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
In cultured neurons and sections of the rat cortex, we found BDNF mRNA associated with Htt and components of neuronal RNA granules, which are centers for regulating RNA transport and local translation.
BDNF Binding (associated) of Htt in neurons
5) Confidence 0.33 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2889995 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

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