INT31719

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Context Info
Confidence 0.47
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.10
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsa) mitochondrion (Ctsa) nucleus (Ctsa)
lysosome (Ctsa)
Anatomy Link Frequency
lung 1
Ctsa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 112 97.88 Very High Very High Very High
metalloproteinase 11 96.64 Very High Very High Very High
fibrosis 3 96.24 Very High Very High Very High
Pain 1 96.12 Very High Very High Very High
cytokine 17 92.80 High High
Inflammatory response 8 89.04 High High
imagery 90 70.88 Quite High
Calcium channel 1 50.28 Quite High
sodium channel 1 49.32 Quite Low
potassium channel 1 41.60 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 99 98.72 Very High Very High Very High
Cleidocranial Dysplasia 45 98.56 Very High Very High Very High
Polyps 120 98.52 Very High Very High Very High
Emphysema 31 98.04 Very High Very High Very High
INFLAMMATION 121 97.88 Very High Very High Very High
Stress 17 96.40 Very High Very High Very High
Fibrosis 3 96.24 Very High Very High Very High
Cancer 120 95.04 Very High Very High Very High
Apoptosis 21 95.04 Very High Very High Very High
Death 4 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antimetastatic effect is accompanied by stabilization of neurohumoral indices, by a decrease in the intensity of lipid peroxidation and of the acid cathepsin activity in the blood vessels and in the lung tissue.
Negative_regulation (decrease) of cathepsin in lung
1) Confidence 0.47 Published 1988 Journal Eksp. Onkol. Section Abstract Doc Link 2899023 Disease Relevance 0.43 Pain Relevance 0.10
Furthermore, we conclude that the decrease in cathepsin activated probe signal was largely due to the loss of MDSCs from areas of dysplasia.
Negative_regulation (decrease) of cathepsin associated with cleidocranial dysplasia
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.37 Pain Relevance 0.30
We therefore postulated that if pro-inflammatory cells were the source of cathepsin activity and played a causative role in polyposis, then suppression of polyposis-associated inflammation should hinder progressive polyp growth, and this therapeutic effect should be reflected in a significant down-regulation of cathepsin activity.
Negative_regulation (regulation) of cathepsin associated with inflammation and polyps
3) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.33 Pain Relevance 0.37
We therefore postulated that if pro-inflammatory cells were the source of cathepsin activity and played a causative role in polyposis, then suppression of polyposis-associated inflammation should hinder progressive polyp growth, and this therapeutic effect should be reflected in a significant down-regulation of cathepsin activity.
Negative_regulation (down) of cathepsin associated with inflammation and polyps
4) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.34 Pain Relevance 0.37
These findings suggest that cathepsin inhibitors might be a useful approach for COPD therapy.


Negative_regulation (inhibitors) of cathepsin associated with pulmonary disease
5) Confidence 0.02 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 1.54 Pain Relevance 0.27
They are comprised of 47 cytoplasmic proteins including 20 cellular structural proteins (such as tubulins, actins, keratins, and microtubule-associated proteins), 25 mitochondrial proteins, 10 nuclear proteins, 6 ER proteins, and 1 lysosomal protein.
Negative_regulation (comprised) of lysosomal protein
6) Confidence 0.02 Published 2007 Journal Proteome Sci Section Body Doc Link PMC2045652 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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