INT317222

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pyy) extracellular region (Pyy)
Anatomy Link Frequency
large intestine 2
Pyy (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 36 77.76 Quite High
qutenza 4 50.68 Quite High
tetrodotoxin 2 50.12 Quite High
antagonist 26 48.12 Quite Low
Potency 4 44.08 Quite Low
member 8 2 41.04 Quite Low
tolerance 32 5.00 Very Low Very Low Very Low
nerve block 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 76.00 Quite High
Impaired Glucose Tolerance 32 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Constipation 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Weight Gain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A similar increasing sensitivity to exogenous PYY and NPY has also been described from the small to the large intestine of the mouse (Cox et al., 2001).
Positive_regulation (increasing) of Gene_expression (exogenous) of PYY in large intestine
1) Confidence 0.43 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0.08 Pain Relevance 0.05
This demonstrates that ablation of PYY or selective blockade of epithelial Y1 receptors (Figure 2B) renders colonic mucosa insensitive to Gpr119 activation, confirming the functional requirement of Gpr119 mucosal signaling for endogenous PYY.
Positive_regulation (requirement) of Gene_expression (mucosal) of PYY
2) Confidence 0.43 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0 Pain Relevance 0.15

General Comments

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