INT317231

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.34
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Gpr119) signal transduction (Gpr119) plasma membrane (Gpr119)
signal transducer activity (Gpr119)
Anatomy Link Frequency
colon 2
descending colon 1
Gpr119 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 52 99.20 Very High Very High Very High
agonist 72 85.76 High High
qutenza 8 70.84 Quite High
member 8 4 61.20 Quite High
tolerance 64 51.76 Quite High
tetrodotoxin 4 11.68 Low Low
Potency 8 5.00 Very Low Very Low Very Low
nerve block 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Constipation 8 93.44 High High
Targeted Disruption 28 71.04 Quite High
Diabetes Mellitus 8 69.48 Quite High
Impaired Glucose Tolerance 64 51.76 Quite High
Weight Gain 4 18.88 Low Low
Stress 8 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was therefore of interest to determine whether selective DPP-IV inhibition amplified Gpr119-activated colonic responses by prolonging the functional half-life of endogenous PYY and/or NPY.


Spec (whether) Negative_regulation (inhibition) of Gpr119-activated
1) Confidence 0.30 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0.34 Pain Relevance 0.05
When glucose was replaced with mannitol in either reservoir (coincident with the side of PSN632408 addition), the Gpr119 responses were significantly reduced in mouse (Figure 4A) and human colon mucosa (Figure 4B).
Negative_regulation (reduced) of Gpr119 in colon
2) Confidence 0.30 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0 Pain Relevance 0.07
A clear regional variation in Gpr119 sensitivity was also observed in WT mouse GI tract (Figure 1C), with apical PSN632408 responses being greatest in the descending colon and least in duodenal mucosa.
Negative_regulation (variation) of Gpr119 in descending colon
3) Confidence 0.29 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0 Pain Relevance 0.17
Also consistent with our mouse tissue studies, Gpr119 responses in human colon were only blocked by the Y1 receptor antagonist, BIBO3304 (Figure 2E).
Negative_regulation (blocked) of Gpr119 in colon associated with antagonist
4) Confidence 0.29 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0 Pain Relevance 0.17

General Comments

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