INT317275

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 22 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
Catecholamine 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Locus ceruleus 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 98 99.98 Very High Very High Very High
Teratocarcinoma 2 64.76 Quite High
Death 28 53.32 Quite High
Disease 176 50.00 Quite Low
Stress 34 40.20 Quite Low
Toxicity 14 5.00 Very Low Very Low Very Low
Apoptosis 14 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our recent results corroborate the notion that a mitochondrial dysfunction induces an oligomerization of alpha-synuclein (Esteves et al., 2010a).
Positive_regulation (induces) of alpha-synuclein Binding (oligomerization) of associated with parkinson's disease
1) Confidence 0.37 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.28 Pain Relevance 0
Moreover, it seems that proteasomal dysfunction may potentiate alpha-synuclein oligomerization, which in turn can have an inhibitory effect on the proteasomal activities.
Spec (may) Positive_regulation (potentiate) of alpha-synuclein Binding (oligomerization) of
2) Confidence 0.27 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.26 Pain Relevance 0

General Comments

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