INT317299

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Park2) Golgi apparatus (Park2) endoplasmic reticulum (Park2)
intracellular (Park2) protein complex (Park2) ligase activity (Park2)
Park2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 1 70.76 Quite High
Dopamine 11 12.96 Low Low
Central nervous system 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
monoamine 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 88 99.36 Very High Very High Very High
Apoptosis 7 97.44 Very High Very High Very High
Parkinson's Disease 49 76.48 Quite High
Death 14 59.44 Quite High
Stress 17 47.68 Quite Low
Toxicity 7 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the formation of the ubiquitin E3 ligase activity complex (by PINK1, DJ-1 and parkin) seems to have a neuroprotective role in mitochondria-mediated apoptosis (Darios et al., 2003; Petit et al., 2005; Gorner et al., 2007).
parkin Binding (formation) of associated with apoptosis
1) Confidence 0.36 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.61 Pain Relevance 0.04

General Comments

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