INT3173

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Context Info
Confidence 0.55
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 28
Total Number 28
Disease Relevance 6.46
Pain Relevance 12.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sct)
Anatomy Link Frequency
pancreas 6
plasma 2
exocrine cells 2
small intestine mucosa 2
papilla 2
Sct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 21 100.00 Very High Very High Very High
tetrodotoxin 4 100.00 Very High Very High Very High
Cholecystokinin 3 100.00 Very High Very High Very High
Serotonin 3 100.00 Very High Very High Very High
depression 2 100.00 Very High Very High Very High
Enkephalin 48 99.98 Very High Very High Very High
Chronic pancreatitis 24 99.96 Very High Very High Very High
narcan 26 99.92 Very High Very High Very High
anesthesia 6 99.78 Very High Very High Very High
gABA 4 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Pancreatitis 24 99.96 Very High Very High Very High
Duodenal Ulcer 16 99.84 Very High Very High Very High
Gastrinoma 2 98.80 Very High Very High Very High
Ulcers 5 97.84 Very High Very High Very High
Fistula 2 97.76 Very High Very High Very High
Cancer 5 95.08 Very High Very High Very High
Syndrome 7 92.12 High High
Diabetes Mellitus 12 91.84 High High
Alcohol Addiction 2 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The release of secretin by SRP was abolished in rats treated with TTX, mucosal or perivagal application of capsaicin, MEK or vagotomy.
Negative_regulation (abolished) of Localization (release) of secretin associated with qutenza and enkephalin
1) Confidence 0.55 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075453 Disease Relevance 0 Pain Relevance 0.63
These results suggest that in the rat, MEK inhibition of acid-stimulated pancreatic secretion and secretin release involves suppression of SRP activity release.
Negative_regulation (inhibition) of Localization (release) of secretin associated with enkephalin
2) Confidence 0.46 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11292597 Disease Relevance 0 Pain Relevance 1.14
In chronic pancreatitis, secretin releasing response to acidification was markedly impaired, in addition, inhibition of secretin release by bicarbonate was diminished due to a lack of bicarbonate flow from the pancreas.
Negative_regulation (diminished) of Localization (release) of secretin in pancreas associated with chronic pancreatitis
3) Confidence 0.43 Published 1978 Journal Gastroenterol. Jpn. Section Abstract Doc Link 648803 Disease Relevance 0.92 Pain Relevance 0.33
In chronic pancreatitis, secretin releasing response to acidification was markedly impaired, in addition, inhibition of secretin release by bicarbonate was diminished due to a lack of bicarbonate flow from the pancreas.
Negative_regulation (inhibition) of Localization (release) of secretin in pancreas associated with chronic pancreatitis
4) Confidence 0.43 Published 1978 Journal Gastroenterol. Jpn. Section Abstract Doc Link 648803 Disease Relevance 0.92 Pain Relevance 0.33
It is suggested that the secretin release was impaired in duodenal ulcer in spite of hypersecretion of gastric acids.
Negative_regulation (impaired) of Localization (release) of secretin associated with duodenal ulcer
5) Confidence 0.43 Published 1978 Journal Gastroenterol. Jpn. Section Abstract Doc Link 648803 Disease Relevance 0.92 Pain Relevance 0.32
Impaired secretin release and reduced duodenal S-cells have been documented in peptic ulcer patients compared with control patients.
Negative_regulation (Impaired) of Localization (release) of secretin associated with ulcers
6) Confidence 0.43 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18280672 Disease Relevance 0.81 Pain Relevance 0.12
Moreover, the action of CAP on secretin release was significantly inhibited in the recipient rats pretreated with TTX, BSV, and topical applications of capsaicin but was not suppressed in the recipient rats pretreated with atropine, hexamethonium, or propranolol.
Neg (not) Negative_regulation (suppressed) of Localization (release) of secretin associated with tetrodotoxin and qutenza
7) Confidence 0.41 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653572 Disease Relevance 0 Pain Relevance 0.55
Stimulation of PES and inhibition of gastric acid secretion and motility by secretin in a physiological dose are also dependent on the vagal afferent pathway as these effects of secretin are abolished by perivagal capsaicin treatment or vagotomy.
Negative_regulation (inhibition) of Localization (secretion) of secretin associated with qutenza
8) Confidence 0.40 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075453 Disease Relevance 0 Pain Relevance 0.70
Secretin significantly inhibited pentagastrin-stimulated acid secretion by 63% (P < 0.01), which was abolished by both vagotomy and PV treatment of Cap in conscious rats.
Negative_regulation (abolished) of Localization (secretion) of Secretin associated with qutenza
9) Confidence 0.38 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9655680 Disease Relevance 0 Pain Relevance 0.52
This study was designed to improve our understanding of duodeno-pancreatic reflexes, the existence of which was suggested by the previous observation of a reduction in secretin-stimulated pancreatic secretion during local anesthesia of the duodenal mucosa.
Negative_regulation (reduction) of Localization (secretion) of secretin associated with anesthesia
10) Confidence 0.37 Published 1985 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 4020032 Disease Relevance 0 Pain Relevance 0.24
In chronic pancreatitis, secretin releasing response to acidification was markedly impaired, in addition, inhibition of secretin release by bicarbonate was diminished due to a lack of bicarbonate flow from the pancreas.
Negative_regulation (impaired) of Localization (releasing) of secretin in pancreas associated with chronic pancreatitis
11) Confidence 0.37 Published 1978 Journal Gastroenterol. Jpn. Section Abstract Doc Link 648803 Disease Relevance 0.93 Pain Relevance 0.33
GABA-stimulated secretin secretion was inhibited by both somatostatin and metenkephalin, suggesting that GABA-stimulated secretin secretion may be under the inhibitory control of peptidergic agents as well.
Negative_regulation (inhibited) of Localization (secretion) of secretin associated with gaba and somatostatin
12) Confidence 0.36 Published 1986 Journal Peptides Section Abstract Doc Link 2875446 Disease Relevance 0 Pain Relevance 0.49
MEK inhibits secretin release and pancreatic secretion: roles of secretin-releasing peptide and somatostatin.
Negative_regulation (inhibits) of Localization (secretion) of secretin associated with narcan and somatostatin
13) Confidence 0.34 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 11292597 Disease Relevance 0 Pain Relevance 1.01
MEK inhibits secretin release and pancreatic secretion: roles of secretin-releasing peptide and somatostatin.
Negative_regulation (inhibits) of Localization (release) of secretin associated with narcan and somatostatin
14) Confidence 0.34 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 11292597 Disease Relevance 0 Pain Relevance 1.00
MEK increased plasma SS concentration and inhibited secretin release and pancreatic fluid and bicarbonate secretion dose-dependently.
Negative_regulation (inhibited) of Localization (release) of secretin in plasma associated with somatostatin and enkephalin
15) Confidence 0.34 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11292597 Disease Relevance 0 Pain Relevance 1.27
In 14 duodenal Thomas fistula dogs, four of them alcohol-fed for two years, lidocaine, applied topically to the duodenal pancreatic papilla, inhibited secretin-induced pancreatic secretion probably by interrupting duodenopancreatic reflexes that contribute to the "pancreon's" cholinergic tone.
Negative_regulation (inhibited) of Localization (secretion) of secretin-induced in papilla associated with fistula, lidocaine and alcohol
16) Confidence 0.32 Published 1976 Journal Am. J. Gastroenterol. Section Abstract Doc Link 793379 Disease Relevance 0.16 Pain Relevance 0.46
It is postulated that the modifications elicited by lidocaine sprayed topically and infused intravenously on CCK plus secretin evoked pancreatic secretion plateau levels are due to depression of an anti-CCK factor secreted by the small intestine mucosa.
Negative_regulation (depression) of Localization (secretion) of secretin in small intestine mucosa associated with depression and lidocaine
17) Confidence 0.32 Published 1976 Journal Am. J. Gastroenterol. Section Abstract Doc Link 793379 Disease Relevance 0.25 Pain Relevance 0.64
Reduction of secretin secretion diminished secretion of bicarbonates and mucus with simultaneous change in the quality of mucous gel.
Negative_regulation (Reduction) of Localization (secretion) of secretin
18) Confidence 0.32 Published 2009 Journal Ter. Arkh. Section Body Doc Link 19334494 Disease Relevance 0.05 Pain Relevance 0
An anti-GRP antiserum inhibited the EFS-enhanced secretin-induced secretions of fluid and amylase by 12 and 43%, respectively, whereas a simultaneous infusion of the antiserum and atropine completely abolished them.
Negative_regulation (inhibited) of Localization (secretions) of secretin
19) Confidence 0.29 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10762609 Disease Relevance 0 Pain Relevance 0.10
Reduction of secretin secretion diminished secretion of bicarbonates and mucus with simultaneous change in the quality of mucous gel.
Negative_regulation (diminished) of Localization (secretion) of secretin
20) Confidence 0.23 Published 2009 Journal Ter. Arkh. Section Body Doc Link 19334494 Disease Relevance 0 Pain Relevance 0

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