INT317300

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Park2, Pink1) cytoplasm (Park2, Pink1) cytosol (Park2, Pink1)
Golgi apparatus (Park2) endoplasmic reticulum (Park2) intracellular (Park2)
Anatomy Link Frequency
posterior 1
Park2 (Rattus norvegicus)
Pink1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 22 27.84 Quite Low
Central nervous system 6 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
Catecholamine 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Locus ceruleus 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 176 98.44 Very High Very High Very High
Death 28 93.92 High High
Toxicity 14 66.44 Quite High
Neurodegenerative Disease 8 65.92 Quite High
Parkinson's Disease 98 33.44 Quite Low
Stress 34 23.36 Low Low
Aging 4 19.84 Low Low
Apoptosis 14 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PINK1 also interacts with Parkin which is responsible for PINK1 homeostasis by ubiquitination and posterior degradation via UPS (Deas et al., 2009).
Parkin Binding (interacts) of PINK1 in posterior
1) Confidence 0.48 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.61 Pain Relevance 0
PINK1 and parkin also form a functional E3 ligase complex with DJ-1, which promotes degradation of misfolded parkin substrates by UPS, including parkin itself and synphilin-1.
parkin Binding (complex) of PINK1
2) Confidence 0.36 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.62 Pain Relevance 0

General Comments

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