INT317307

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hsp90aa1, Pink1) response to stress (Hsp90aa1, Pink1) cytoplasm (Hsp90aa1, Pink1)
unfolded protein binding (Hsp90aa1) protein folding (Hsp90aa1) mitochondrion (Pink1)
Hsp90aa1 (Mus musculus)
Pink1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 11 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
monoamine 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Eae 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 14 99.92 Very High Very High Very High
Disease 88 97.64 Very High Very High Very High
Toxicity 7 72.44 Quite High
Neurodegenerative Disease 4 41.44 Quite Low
Parkinson's Disease 49 39.44 Quite Low
Stress 17 29.36 Quite Low
Aging 2 25.84 Quite Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PINK1 interacts with several chaperons, like Hsp90 and Cdc37, and loss of this interaction can contribute to PD pathogenesis (Moriwaki et al., 2008).
Hsp90 Binding (interacts) of PINK1 associated with disease
1) Confidence 0.12 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.56 Pain Relevance 0

General Comments

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