INT317313

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Snca) histone binding (Snca) enzyme binding (Snca)
cytoplasm (Snca) cytosol (Snca) ATPase activity (Atp13a2)
Anatomy Link Frequency
primary neuron 1
Atp13a2 (Mus musculus)
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 11 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
monoamine 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Eae 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 7 99.40 Very High Very High Very High
Parkinson's Disease 49 85.52 High High
Disease 88 83.12 Quite High
Targeted Disruption 6 71.56 Quite High
Stress 17 5.00 Very Low Very Low Very Low
Death 14 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, ATP13A2 suppresses alpha-synuclein and manganese toxicity in primary neuron cultures (Gitler et al., 2009).
ATP13A2 Negative_regulation (suppresses) of alpha-synuclein in primary neuron associated with toxicity
1) Confidence 0.13 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.59 Pain Relevance 0

General Comments

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