INT317319

Context Info Confidence 0.26 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.67 Pain Relevance 0

mitochondrion (Trap1, Pink1) response to stress (Trap1, Pink1) cytosol (Pink1) unfolded protein binding (Trap1) protein folding (Trap1) kinase activity (Pink1)

Trap1 (Mus musculus) Pink1 (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 33 5.00 Central nervous system 9 5.00 midbrain 6 5.00 Catecholamine 6 5.00 Glutamate 6 5.00 Locus ceruleus 3 5.00 gABA 3 5.00 monoamine 3 5.00 Substantia nigra 3 5.00 Eae 3 5.00

Disease Link Frequency Relevance Heat Stress 51 100.00 Apoptosis 21 100.00 Necrosis 3 100.00 Shock 3 100.00 Cancer 3 100.00 Targeted Disruption 18 89.12 Disease 264 79.76 Parkinson's Disease 147 61.04 Death 42 43.28 Drug Induced Neurotoxicity 6 36.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, Deas et al. review that PINK1 protects cells against oxidative stress induced apoptosis by interacting with the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1)/heat shock protein 75 (Hsp75) (Pridgeon et al., 2007).

TRAP1 Binding (interacting) of PINK1 associated with stress, necrosis, cancer, shock and apoptosis

1) Confidence 0.26 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.89 Pain Relevance 0

Moreover, Deas et al. review that PINK1 protects cells against oxidative stress induced apoptosis by interacting with the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1)/heat shock protein 75 (Hsp75) (Pridgeon et al., 2007).

Hsp75 Binding (interacting) of PINK1 associated with stress, necrosis, cancer, shock and apoptosis

2) Confidence 0.26 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.89 Pain Relevance 0

Moreover, Deas et al. review that PINK1 protects cells against oxidative stress induced apoptosis by interacting with the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1)/heat shock protein 75 (Hsp75) (Pridgeon et al., 2007).

tumor necrosis factor receptor-associated protein 1 Binding (interacting) of PINK1 associated with stress, necrosis, cancer, shock and apoptosis

3) Confidence 0.26 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.89 Pain Relevance 0

General Comments

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