INT317319

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Trap1, Pink1) response to stress (Trap1, Pink1) cytosol (Pink1)
unfolded protein binding (Trap1) protein folding (Trap1) kinase activity (Pink1)
Trap1 (Mus musculus)
Pink1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 33 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
monoamine 3 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 51 100.00 Very High Very High Very High
Apoptosis 21 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Shock 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Targeted Disruption 18 89.12 High High
Disease 264 79.76 Quite High
Parkinson's Disease 147 61.04 Quite High
Death 42 43.28 Quite Low
Drug Induced Neurotoxicity 6 36.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, Deas et al. review that PINK1 protects cells against oxidative stress induced apoptosis by interacting with the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1)/heat shock protein 75 (Hsp75) (Pridgeon et al., 2007).
TRAP1 Binding (interacting) of PINK1 associated with stress, necrosis, cancer, shock and apoptosis
1) Confidence 0.26 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.89 Pain Relevance 0
Moreover, Deas et al. review that PINK1 protects cells against oxidative stress induced apoptosis by interacting with the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1)/heat shock protein 75 (Hsp75) (Pridgeon et al., 2007).
Hsp75 Binding (interacting) of PINK1 associated with stress, necrosis, cancer, shock and apoptosis
2) Confidence 0.26 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.89 Pain Relevance 0
Moreover, Deas et al. review that PINK1 protects cells against oxidative stress induced apoptosis by interacting with the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1)/heat shock protein 75 (Hsp75) (Pridgeon et al., 2007).
tumor necrosis factor receptor-associated protein 1 Binding (interacting) of PINK1 associated with stress, necrosis, cancer, shock and apoptosis
3) Confidence 0.26 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.89 Pain Relevance 0

General Comments

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