INT317322

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca, Th) mitochondrion (Snca, Th) nucleus (Snca, Th)
cytoplasm (Snca, Th) oxidoreductase activity (Th) histone binding (Snca)
Snca (Mus musculus)
Th (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 1 98.00 Very High Very High Very High
Dopamine 11 93.32 High High
Catecholamine 2 90.48 High High
Central nervous system 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Eae 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 14 78.80 Quite High
Stress 17 77.88 Quite High
Drug Induced Neurotoxicity 2 73.20 Quite High
Disease 88 50.00 Quite Low
Parkinson's Disease 49 37.00 Quite Low
Neurodegenerative Disease 4 28.64 Quite Low
Toxicity 7 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also suggested that alpha-synuclein may modulate the activation of tyrosine hydroxylase (Perez et al., 2002) and down-regulate vesicular monoamine transporter-2 activity (Guo et al., 2008).
alpha-synuclein Spec (may) Regulation (modulate) of Positive_regulation (activation) of tyrosine hydroxylase associated with monoamine
1) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.23 Pain Relevance 0.17

General Comments

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