INT317324

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Park7, SNCAIP) nucleus (Park7, SNCAIP) mitochondrion (Park7)
mitochondrion organization (Park7) response to stress (Park7) cell proliferation (Park7)
Park7 (Mus musculus)
SNCAIP (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 11 37.20 Quite Low
Central nervous system 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
monoamine 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Eae 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 88 99.84 Very High Very High Very High
Death 14 85.44 High High
Neurodegenerative Disease 4 75.28 Quite High
Toxicity 7 57.96 Quite High
Parkinson's Disease 49 24.96 Low Low
Stress 17 14.88 Low Low
Aging 2 11.36 Low Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PINK1 and parkin also form a functional E3 ligase complex with DJ-1, which promotes degradation of misfolded parkin substrates by UPS, including parkin itself and synphilin-1.
DJ-1 Positive_regulation (promotes) of Protein_catabolism (degradation) of synphilin-1
1) Confidence 0.38 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.69 Pain Relevance 0

General Comments

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