INT317356

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Context Info
Confidence 0.80
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.74
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
Acc (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 48 90.48 High High
tolerance 24 85.44 High High
ischemia 12 68.96 Quite High
ketamine 12 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 40 93.44 High High
Targeted Disruption 20 91.76 High High
Obesity 8 77.60 Quite High
Coronary Heart Disease 16 75.00 Quite High
Cv Unclassified Under Development 12 68.96 Quite High
Toxicity 28 54.40 Quite High
Hyperinsulinism 4 42.56 Quite Low
Alcoholic Cardiomyopathy 16 23.20 Low Low
Body Weight 4 20.72 Low Low
Stress 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More interestingly, the ADH and/or acute ethanol-induced cardiac contractile and intracellular Ca2+ responses were coordinated with hyperactivated AMPK signaling cascade including phosphorylation of AMPK, ACC and LKB1 as well as downregulation of protein phosphatase PP2A subunit and PPAR-?.
Phosphorylation (phosphorylation) of ACC
1) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.40 Pain Relevance 0.08
ADH transgene itself did not elicit any effect on the phosphorylation of AMPK and ACC (Fig. 7).
Phosphorylation (phosphorylation) of ACC
2) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
, anti-Glut4, anti-AMPK, anti-phosphorylated AMPK (pAMPK, Thr172), anti-ACC, anti-phosphorylated ACC (pACC, Ser79), anti-LKB1, anti-phosphorylated LKB1 (pLKB1, Ser428), anti-PP2AA, anti-PP2AB, anti-PP2C?
Phosphorylation (phosphorylated) of ACC
3) Confidence 0.79 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
, as well as phosphorylation of AMPK, ACC and LKB1, all of which except plasma insulin were overtly accentuated by ADH transgene.
Phosphorylation (phosphorylation) of ACC in plasma
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890411 Disease Relevance 0.33 Pain Relevance 0.15

General Comments

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