INT317359

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.93
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hearts 1
Amp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 25 98.84 Very High Very High Very High
alcohol 96 95.20 Very High Very High Very High
tolerance 49 72.80 Quite High
Kinase C 1 61.20 Quite High
agonist 23 42.52 Quite Low
ketamine 24 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 25 98.84 Very High Very High Very High
Obesity 23 93.60 High High
Body Weight 8 89.48 High High
Diabetes Mellitus 24 84.76 Quite High
Neurodegenerative Disease 8 84.36 Quite High
Impaired Glucose Tolerance 81 73.44 Quite High
Targeted Disruption 46 72.48 Quite High
Cancer 3 68.48 Quite High
Injury 9 62.16 Quite High
Reperfusion Injury 9 51.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Physiological stimuli such as ischemia reperfusion, hormones and nutrients may activate AMPK by elevating intracellular AMP/ATP ratio.
Positive_regulation (elevating) of AMP associated with ischemia
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.26 Pain Relevance 0.09
While neither acute ethanol exposure nor ADH overtly affected cardiac ATP levels, acute ethanol treatment significantly elevated the AMP levels and AMP/ATP ratio in both mouse groups with a more pronounced increase in AMP/ATP ratio in the ADH mice.
Positive_regulation (increase) of AMP
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.09 Pain Relevance 0.09
, ACC and LKB1 associated with enhanced AMP-to-ATP ratio in hearts following acute ethanol exposure.
Positive_regulation (enhanced) of AMP in hearts
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.54 Pain Relevance 0.11
Data from our current study revealed an elevation in cardiac AMP-to-ATP ratio following acute ethanol challenge with a further raise in the ADH ethanol-treated mice.
Positive_regulation (elevation) of AMP
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.25 Pain Relevance 0.08
While neither acute ethanol exposure nor ADH overtly affected cardiac ATP levels, acute ethanol treatment significantly elevated the AMP levels and AMP/ATP ratio in both mouse groups with a more pronounced increase in AMP/ATP ratio in the ADH mice.
Positive_regulation (elevated) of AMP
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.09 Pain Relevance 0.09
Typically, elevation of intracellular AMP or the AMP-to-ATP ratio serves as the main activator of AMPK through several mechanisms.
Positive_regulation (elevation) of AMP
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.24 Pain Relevance 0.08
Typically, elevation of intracellular AMP or the AMP-to-ATP ratio serves as the main activator of AMPK through several mechanisms.
Positive_regulation (elevation) of AMP
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.24 Pain Relevance 0.08
While neither acute ethanol exposure nor ADH overtly affected cardiac ATP levels, acute ethanol treatment significantly elevated the AMP levels and AMP/ATP ratio in both mouse groups with a more pronounced increase in AMP/ATP ratio in the ADH mice.
Positive_regulation (elevated) of AMP
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.09 Pain Relevance 0.09
Elevated level of AMP induces allosteric stimulation of AMPK.
Positive_regulation (Elevated) of AMP
9) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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