INT317394

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.89
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Stk11) mitochondrion (Stk11) nucleus (Stk11)
cell cycle (Stk11) protein complex (Stk11) kinase activity (Stk11)
Anatomy Link Frequency
hearts 1
Stk11 (Mus musculus)
Amp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 9 86.12 High High
tolerance 18 72.80 Quite High
alcohol 36 51.60 Quite High
ketamine 9 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 9 86.12 High High
Diabetes Mellitus 6 85.60 High High
Neurodegenerative Disease 3 85.20 High High
Obesity 6 74.00 Quite High
Impaired Glucose Tolerance 30 73.44 Quite High
Injury 3 62.16 Quite High
Targeted Disruption 15 52.88 Quite High
Reperfusion Injury 3 51.68 Quite High
Coronary Heart Disease 12 50.00 Quite Low
Alcoholic Cardiomyopathy 12 49.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, ACC and LKB1 associated with enhanced AMP-to-ATP ratio in hearts following acute ethanol exposure.
LKB1 Binding (associated) of AMP in hearts
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.55 Pain Relevance 0.11
Last, the binding of AMP to AMPK renders it a better substrate for LKB1 and reduces its substrate affinity for protein phosphatase [22], [23], [24].
LKB1 Binding (binding) of AMP
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.20 Pain Relevance 0.06
The AMPK upstream kinase LKB1 kinase monitors the levels of glucose and the AMP/ATP ratio, governing the Thr172 phosphorylation of the ?
LKB1 Binding (ratio) of AMP
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

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