INT3174

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Context Info
Confidence 0.38
First Reported 1978
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 43
Total Number 48
Disease Relevance 20.95
Pain Relevance 13.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 12
plasma 2
microglial cells 2
liver 1
choroid plexus 1
Ptger2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 5 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
Calcitonin gene-related peptide 5 99.80 Very High Very High Very High
Morphine 4 99.48 Very High Very High Very High
agonist 57 99.44 Very High Very High Very High
cINOD 64 99.32 Very High Very High Very High
Pain 74 99.12 Very High Very High Very High
antagonist 51 99.12 Very High Very High Very High
Inflammation 389 98.44 Very High Very High Very High
gABA 14 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fever 240 100.00 Very High Very High Very High
Cancer 15 100.00 Very High Very High Very High
Depression 2 100.00 Very High Very High Very High
Hyperalgesia 28 99.76 Very High Very High Very High
Stress 56 99.30 Very High Very High Very High
Pain 74 99.12 Very High Very High Very High
Injury 39 99.04 Very High Very High Very High
Keloid Scars 2 98.80 Very High Very High Very High
Wound Healing 7 98.68 Very High Very High Very High
INFLAMMATION 516 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, when pentobarbital, diazepam, isoniazid and strychnine were perfused i.c.v., the diuretic action of PGE2 was diminished and antidiuresis in response to PGE2 remained unchanged.
Negative_regulation (diminished) of PGE2
1) Confidence 0.38 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 651016 Disease Relevance 0.08 Pain Relevance 0.21
PGE2 and its metabolites are eliminated rapidly from the circulation, thus plasma levels are not useful in assessing clinical efficacy.
Negative_regulation (eliminated) of PGE2 in plasma
2) Confidence 0.34 Published 1993 Journal J Reprod Med Section Abstract Doc Link 8429532 Disease Relevance 0.06 Pain Relevance 0.05
In the present study, propiverine significantly decreased BP only, the basal tension of the bladder, in the intravesical PGE2 group and showed no effect on MP, BC, VV, or MI.
Negative_regulation (decreased) of PGE2 in bladder
3) Confidence 0.34 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855469 Disease Relevance 0.55 Pain Relevance 0.06
The effects of PGE2 on IPSCs were unaffected by the selective EP1 antagonist, SC-51322.
Neg (unaffected) Negative_regulation (unaffected) of PGE2 in PGE2 associated with antagonist
4) Confidence 0.32 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10520139 Disease Relevance 0 Pain Relevance 0.55
To confirm the conclusion, we studied the effect of a specific membrane impermeant PKA inhibitor, PKA-I, on the PGE2 action (Fig. 5B).
Negative_regulation (inhibitor) of PGE2
5) Confidence 0.26 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0
We chose to measure currents following a brief (2 min) application of PGE2 (1 ?
Negative_regulation (application) of PGE2
6) Confidence 0.26 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0
Direct administration of PGE2 into the brain has also been shown to reduce microglial activation and TNF-?
Negative_regulation (administration) of PGE2 in brain
7) Confidence 0.23 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.72 Pain Relevance 0.19
Hisakawa et al. [34] observed a depletion of PGE2 in human synovial fibroblasts by soluble ferric citrate, which could be reversed by the presence of desferrioxamine.
Negative_regulation (depletion) of PGE2 in fibroblasts
8) Confidence 0.16 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.32 Pain Relevance 0.11
On the other hand, the levels of PGE-2 in the inflamed hind-paw were unaffected by the administration of this bisphosphonate.
Neg (unaffected) Negative_regulation (unaffected) of PGE-2 in paw
9) Confidence 0.15 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17664076 Disease Relevance 0.90 Pain Relevance 0.87
Cold restraint stress produced haemorrhagic lesions and reduced PGE2 and CGRP levels in the stomach, with an increase in MPO activity and NO levels.
Negative_regulation (reduced) of PGE2 in stomach associated with stress, urological neuroanatomy and calcitonin gene-related peptide
10) Confidence 0.15 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 17002672 Disease Relevance 1.03 Pain Relevance 0.52
Selective targeting of dorsal horn microglia with the Mac-1-SAP immunotoxin, a chemical conjugate of mouse monoclonal antibody to CD11b and the ribosome-inactivating protein saporin, resulted in reduced microglia staining, reduction in PGE2 levels, and reversed pain-related behaviors [corrected].
Negative_regulation (reduction) of PGE2 in dorsal horn associated with pain and dorsal horn
11) Confidence 0.14 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17329433 Disease Relevance 0.34 Pain Relevance 0.43
In contrast, long-term exposure (3 h) induced a large amount of PGE2 release, which was completely abolished by indomethacin or NS-398.
Negative_regulation (abolished) of PGE2 in PGE2
12) Confidence 0.12 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16580130 Disease Relevance 0.39 Pain Relevance 0.76
m Fe2O3 particles in the presence of PGE2 synthesis inhibitor, indomethacin.
Negative_regulation (inhibitor) of PGE2
13) Confidence 0.12 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.35 Pain Relevance 0.22
Dynorphin (1-13), stimulated insulin release at a concentration of 6 X 10(-9) M, while lowering islet PGE2.
Negative_regulation (lowering) of PGE2 associated with dynorphin
14) Confidence 0.11 Published 1988 Journal Life Sci. Section Abstract Doc Link 2898715 Disease Relevance 0.07 Pain Relevance 0.38
decrease in the levels of PGE2 and TNF-?
Negative_regulation (decrease) of PGE2
15) Confidence 0.10 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1852887 Disease Relevance 0.56 Pain Relevance 0.22
Binding to albumin prevents the rapid enzymatic inactivation of PGE2 [37,38], thus allowing it to reach a distant site.
Negative_regulation (inactivation) of PGE2
16) Confidence 0.09 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.43 Pain Relevance 0
Hence, the increased circulating level of PGE2 at the onset of the first febrile phase may be explained by the following enzymatic events in the lung and liver: production of arachidonic acid by activated (phosphorylated) cPLA2 ?
Negative_regulation (explained) of PGE2 in lung associated with fever
17) Confidence 0.07 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.67 Pain Relevance 0.08
A good candidate for such a site is the preoptic hypothalamus, which is highly sensitive to the pyrogenic effect of PGE2 [39].
Negative_regulation (effect) of PGE2 in hypothalamus
18) Confidence 0.07 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.43 Pain Relevance 0
These data implies that suppression of PGE2 activity may induce the expression of spinal COX-2 in Freund's adjuvant-induced pain model.
Negative_regulation (suppression) of PGE2 in spinal associated with pain
19) Confidence 0.07 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15193428 Disease Relevance 0.51 Pain Relevance 1.12
The hyperalgesic effects of PGE2 were reversed potently by morphine (0.32-3.2 mg/kg), and the effects of morphine were antagonized in a surmountable manner by both the opioid antagonist quadazocine (0.1 mg/kg) and by systemic administration of the charged opioid antagonist quaternary naltrexone (3.2 mg/kg).
Negative_regulation (reversed) of PGE2 associated with hyperalgesia, antagonist, opioid and morphine
20) Confidence 0.06 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8371142 Disease Relevance 0.65 Pain Relevance 1.24

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