INT317403

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Prkag1 (Mus musculus)
Amp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 6 78.08 Quite High
alcohol 24 51.60 Quite High
tolerance 12 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 6 78.08 Quite High
Obesity 4 74.00 Quite High
Targeted Disruption 10 52.88 Quite High
Coronary Heart Disease 8 50.00 Quite Low
Stress 8 17.76 Low Low
Impaired Glucose Tolerance 20 17.72 Low Low
Apoptosis 4 16.88 Low Low
Toxicity 14 15.52 Low Low
Alcoholic Cardiomyopathy 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The AMPK upstream kinase LKB1 kinase monitors the levels of glucose and the AMP/ATP ratio, governing the Thr172 phosphorylation of the ?
Negative_regulation (governing) of AMPK Binding (ratio) of AMP
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.14 Pain Relevance 0.04
Last, the binding of AMP to AMPK renders it a better substrate for LKB1 and reduces its substrate affinity for protein phosphatase [22], [23], [24].
Negative_regulation (reduces) of AMPK Binding (binding) of AMP
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.20 Pain Relevance 0.06

General Comments

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