INT31742

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Context Info
Confidence 0.54
First Reported 1988
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.19
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
paw 1
striatum 1
RPL7AP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 100.00 Very High Very High Very High
Opioid 14 99.76 Very High Very High Very High
Hyperesthesia 2 99.48 Very High Very High Very High
Pain 2 99.48 Very High Very High Very High
nociceptor 1 99.48 Very High Very High Very High
allodynia 7 98.80 Very High Very High Very High
methadone 6 97.18 Very High Very High Very High
Mexiletine 6 96.92 Very High Very High Very High
intrathecal 1 94.16 High High
lidocaine 1 83.60 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 98.80 Very High Very High Very High
Catalepsy 12 97.54 Very High Very High Very High
Nociception 4 97.52 Very High Very High Very High
Nervous System Injury 2 87.20 High High
Cv Unclassified Under Development 1 67.12 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat.
Negative_regulation (inhibition) of AP-7 in paw associated with nociception, hyperesthesia, allodynia and mexiletine
1) Confidence 0.54 Published 1997 Journal Pain Section Title Doc Link 9313270 Disease Relevance 0.67 Pain Relevance 1.07
The potentiation of methadone-induced catalepsy in decorticated rats was mimicked in naive rats by intrastriatal (i.s.) application of 2-amino-7-phosphonoheptanoic acid (AP7), a potent and selective antagonist of N-methyl-D-aspartate (NMDA) receptors.
Negative_regulation (antagonist) of AP7 associated with catalepsy, antagonist and methadone
2) Confidence 0.02 Published 1988 Journal Brain Res. Section Abstract Doc Link 2899450 Disease Relevance 0.22 Pain Relevance 0.93
The failure of AP7 to elicit an effect after injection into the n. accumbens fits with the possibility of a selective involvement of the striatum in this phenomenon.
Negative_regulation (failure) of AP7 in striatum
3) Confidence 0.02 Published 1988 Journal Brain Res. Section Abstract Doc Link 2899450 Disease Relevance 0.30 Pain Relevance 1.08

General Comments

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