INT317427

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (ISYNA1) cytoplasm (ISYNA1)
Anatomy Link Frequency
macrophages 1
IFN1@ (Homo sapiens)
ISYNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 99.18 Very High Very High Very High
Tetrahydrobiopterin 4 98.52 Very High Very High Very High
Inflammatory mediators 1 81.44 Quite High
Inflammation 6 76.56 Quite High
Central nervous system 52 50.00 Quite Low
Inflammatory stimuli 1 34.40 Quite Low
intrathecal 10 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 82.76 Quite High
INFLAMMATION 9 81.04 Quite High
Stress 1 69.92 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 95 61.44 Quite High
Infection 38 61.12 Quite High
Necrosis 1 46.64 Quite Low
Cancer 1 46.28 Quite Low
Injury 7 35.60 Quite Low
Opportunistic Infections 5 20.60 Low Low
Viral Meningitis 17 19.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BH4 is also cofactor of the cytokine-inducible enzyme nitric oxide synthase (iNOS), one of the most important cytotoxic reactions of macrophages stimulated by IFN-?.
IFN Positive_regulation (stimulated) of iNOS in macrophages associated with tetrahydrobiopterin and cytokine
1) Confidence 0.12 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.49 Pain Relevance 0.45

General Comments

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