INT317427

Context Info Confidence 0.12 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.49 Pain Relevance 0.45

isomerase activity (ISYNA1) cytoplasm (ISYNA1)

Anatomy Link Frequency macrophages 1 IFN1@ (Homo sapiens) ISYNA1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 9 99.18 Tetrahydrobiopterin 4 98.52 Inflammatory mediators 1 81.44 Inflammation 6 76.56 Central nervous system 52 50.00 Inflammatory stimuli 1 34.40 intrathecal 10 5.00 drug abuse 1 5.00 Inflammatory marker 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Adhesions 1 82.76 INFLAMMATION 9 81.04 Stress 1 69.92 Acquired Immune Deficiency Syndrome Or Hiv Infection 95 61.44 Infection 38 61.12 Necrosis 1 46.64 Cancer 1 46.28 Injury 7 35.60 Opportunistic Infections 5 20.60 Viral Meningitis 17 19.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

BH4 is also cofactor of the cytokine-inducible enzyme nitric oxide synthase (iNOS), one of the most important cytotoxic reactions of macrophages stimulated by IFN-?.

IFN Positive_regulation (stimulated) of iNOS in macrophages associated with tetrahydrobiopterin and cytokine

1) Confidence 0.12 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.49 Pain Relevance 0.45

General Comments

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