INT317511

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.33
Pain Relevance 3.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ppp1r9b, Oprm1) cell differentiation (Ppp1r9b) nucleoplasm (Ppp1r9b)
signal transduction (Oprm1) cytoskeleton (Ppp1r9b) nucleus (Ppp1r9b)
Anatomy Link Frequency
dendrite 2
striatum 1
Ppp1r9b (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 176 100.00 Very High Very High Very High
mu opioid receptor 18 100.00 Very High Very High Very High
tolerance 58 99.92 Very High Very High Very High
Periaqueductal grey 36 99.20 Very High Very High Very High
Morphine 274 98.16 Very High Very High Very High
Analgesic 40 97.36 Very High Very High Very High
Opioid 29 95.40 Very High Very High Very High
opiate 3 94.08 High High
Hippocampus 7 89.04 High High
Glutamate 21 86.76 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 37 99.20 Very High Very High Very High
Hypersensitivity 1 64.96 Quite High
Depression 1 62.56 Quite High
Nociception 54 50.00 Quite Low
Congenital Anomalies 1 45.76 Quite Low
Schizophrenia 4 43.44 Quite Low
Stress 3 16.72 Low Low
Pain 7 15.04 Low Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Intractable Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinophilin appears to be associated with the mu opioid receptor (MOR) in striatum and modulates MOR both at the signaling and endocytosis levels.
Spinophilin Regulation (modulates) of MOR in striatum associated with mu opioid receptor
1) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.13 Pain Relevance 1.36
Both MOR and NMDAR are modulated by spinophilin (neurabin II) [73], [74], a dendrite spine marker [75].
neurabin II Regulation (modulated) of MOR in dendrite associated with opioid receptor
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.10 Pain Relevance 1.25
Both MOR and NMDAR are modulated by spinophilin (neurabin II) [73], [74], a dendrite spine marker [75].
spinophilin Regulation (modulated) of MOR in dendrite associated with opioid receptor
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.10 Pain Relevance 1.24

General Comments

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