INT317516

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1, Akt1) plasma membrane (Oprm1, Akt1) transport (Akt1)
aging (Akt1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1)
Oprm1 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 84 100.00 Very High Very High Very High
tolerance 28 96.40 Very High Very High Very High
Morphine 77 94.88 High High
Intracerebroventricular 3 77.00 Quite High
Opioid 14 75.00 Quite High
Glutamate 10 73.80 Quite High
antagonist 8 71.84 Quite High
Analgesic 19 59.04 Quite High
Periaqueductal grey 18 52.40 Quite High
Kinase C 39 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 18 52.40 Quite High
Nociception 7 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of the Akt-nNOS pathway was also reduced by the binding of these proteins to the MOR-HINT1 complex where they remained inactive.
MOR Binding (binding) of Negative_regulation (reduced) of Positive_regulation (activation) of Akt associated with opioid receptor
1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.10 Pain Relevance 1.11

General Comments

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