INT317517

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.22
Pain Relevance 3.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nos1, Oprm1) mitochondrion (Nos1) enzyme binding (Nos1)
signal transducer activity (Oprm1) cytoplasm (Nos1) cytosol (Nos1)
Nos1 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 336 100.00 Very High Very High Very High
tolerance 112 97.52 Very High Very High Very High
Opioid 56 97.52 Very High Very High Very High
Morphine 308 96.00 Very High Very High Very High
antagonist 32 94.52 High High
narcan 4 93.64 High High
Intracerebroventricular 12 76.12 Quite High
Kinase C 156 73.52 Quite High
Glutamate 40 72.92 Quite High
Periaqueductal grey 72 60.48 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 72 60.48 Quite High
Nociception 28 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Intractable Pain 8 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These changes corresponded with a decrease in the association of nNOS with the MOR during this particular interval (Fig. 1, lower panel).
nNOS Binding (association) of MOR associated with opioid receptor
1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 0.89
The HINT1 protein drives the recruitment of Akt and nNOS to the MOR
nNOS Binding (recruitment) of MOR associated with opioid receptor
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.96
The activation of the Akt-nNOS pathway was also reduced by the binding of these proteins to the MOR-HINT1 complex where they remained inactive.
nNOS Binding (complex) of MOR associated with opioid receptor
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.10 Pain Relevance 1.11
These changes corresponded with a decrease in the association of nNOS with the MOR during this particular interval (Fig. 1, lower panel).
nNOS Binding (association) of MOR associated with opioid receptor
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 0.89

General Comments

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