INT317522

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.40
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Akt1, Nos1) cytoplasm (Akt1, Nos1) cytosol (Akt1, Nos1)
nucleus (Akt1, Nos1) plasma membrane (Akt1, Nos1) mitochondrion (Nos1)
Akt1 (Mus musculus)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 336 99.78 Very High Very High Very High
Morphine 308 96.88 Very High Very High Very High
Kinase C 156 95.48 Very High Very High Very High
Analgesic 76 92.92 High High
Calcium channel 4 87.04 High High
nMDA receptor 4 85.00 Quite High
Glutamate 40 79.76 Quite High
Periaqueductal grey 72 72.68 Quite High
agonist 4 57.84 Quite High
Opioid 56 50.00 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 72 72.68 Quite High
Apoptosis 4 69.84 Quite High
Death 4 58.32 Quite High
Nociception 28 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Intractable Pain 8 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 4 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Akt induces a rapid and transient phosphorylation of nNOS Ser1417 (7) resulting in increased NO production (8), release of zinc ions from metallothioneins (9) and recruitment of PKC?
Akt Positive_regulation (induces) of Phosphorylation (phosphorylation) of nNOS Ser1417 associated with kinase c
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.35
The rapid and transient MOR-dependent Akt-mediated nNOS serine1417 phosphorylation followed by sustained CaMKII phosphorylation of serine847 has also been observed for NMDAR-activated PI3K-Akt [38].
Akt Positive_regulation (mediated) of Phosphorylation (phosphorylation) of nNOS associated with opioid receptor
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.50
Moreover, transient Akt-activating phosphorylation of nNOS Ser1417 [38] was followed by a robust increase in CaMKII-mediated inactivating phosphorylation of nNOS Ser847 [57].
Akt Positive_regulation (mediated) of Phosphorylation (phosphorylation) of nNOS Ser1417
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.19 Pain Relevance 1.12
Moreover, transient Akt-activating phosphorylation of nNOS Ser1417 [38] was followed by a robust increase in CaMKII-mediated inactivating phosphorylation of nNOS Ser847 [57].
Akt Positive_regulation (mediated) of Phosphorylation (phosphorylation) of nNOS
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.20 Pain Relevance 1.16

General Comments

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