INT317524

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.06
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a, Grin1) cytoplasm (Camk2a, Grin1) transport (Grin1)
enzyme binding (Grin1) kinase activity (Camk2a)
Camk2a (Mus musculus)
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 168 99.84 Very High Very High Very High
tolerance 56 98.42 Very High Very High Very High
analgesia 8 98.12 Very High Very High Very High
Morphine 154 97.92 Very High Very High Very High
Kinase C 78 93.28 High High
Analgesic 38 76.20 Quite High
addiction 2 60.56 Quite High
Periaqueductal grey 36 56.20 Quite High
Opioid 28 52.40 Quite High
Calcium channel 2 52.24 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 36 56.20 Quite High
Nociception 14 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Intractable Pain 4 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CaMKII, a Ca2+-CaM-activated protein kinase that is highly abundant in the CNS, has emerged as a critical factor in the NMDAR to MOR section of the regulatory loop.
CaMKII Binding (emerged) of NMDAR associated with opioid receptor
1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.17
The efficacy of the described treatments in preventing and rescuing morphine analgesia from tolerance can be explained by linking early events with those responsible for sustained NMDAR potentiation and subsequent CaMKII action on MORs.
CaMKII Binding (potentiation) of NMDAR associated with tolerance, analgesia and morphine
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 1.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox