INT317531

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Grin1 (Mus musculus)
Mors1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 28 98.94 Very High Very High Very High
analgesia 4 98.64 Very High Very High Very High
Morphine 77 98.44 Very High Very High Very High
opioid receptor 84 93.32 High High
Kinase C 39 92.12 High High
Analgesic 19 77.24 Quite High
Periaqueductal grey 18 57.24 Quite High
Opioid 14 53.44 Quite High
addiction 1 24.12 Low Low
Glutamate 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 18 57.24 Quite High
Nociception 7 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The efficacy of the described treatments in preventing and rescuing morphine analgesia from tolerance can be explained by linking early events with those responsible for sustained NMDAR potentiation and subsequent CaMKII action on MORs.
Regulation (responsible) of NMDAR Binding (potentiation) of MORs associated with tolerance, analgesia and morphine
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 1.05

General Comments

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