INT317540

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a, Oprm1) signal transduction (Oprm1) kinase activity (Camk2a)
signal transducer activity (Oprm1) cytoplasm (Camk2a)
Camk2a (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 168 100.00 Very High Very High Very High
Kinase C 78 97.44 Very High Very High Very High
Morphine 154 91.20 High High
tolerance 56 78.80 Quite High
Calcium channel 2 56.40 Quite High
nMDA receptor 2 54.36 Quite High
Opioid 28 50.00 Quite Low
addiction 2 50.00 Quite Low
Glutamate 20 49.12 Quite Low
Analgesic 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 36 5.00 Very Low Very Low Very Low
Nociception 14 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Intractable Pain 4 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This MOR to NMDAR activating loop is downregulated by CaMKII-mediated negative feedback to inhibit MOR (20).
CaMKII Negative_regulation (downregulated) of MOR associated with opioid receptor
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.95
This MOR to NMDAR activating loop is downregulated by CaMKII-mediated negative feedback to inhibit MOR (20).
CaMKII Negative_regulation (inhibit) of MOR associated with opioid receptor
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.03

General Comments

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