INT317541

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Oprd1, Akt1) signal transduction (Oprd1, Akt1) plasma membrane (Oprd1, Akt1)
transport (Akt1) aging (Akt1) enzyme binding (Akt1)
Oprd1 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 84 100.00 Very High Very High Very High
antagonist 8 100.00 Very High Very High Very High
Morphine 77 98.52 Very High Very High Very High
tolerance 28 88.96 High High
Opioid 14 75.00 Quite High
Intracerebroventricular 3 60.00 Quite High
Glutamate 10 56.80 Quite High
Analgesic 19 42.04 Quite Low
Periaqueductal grey 18 35.40 Quite Low
Kinase C 39 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 18 35.40 Quite Low
Nociception 7 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The diminished effect of morphine was prevented by LNNA, an inhibitor of nNOS function, and naltrindole, a delta-opioid receptor antagonist that also inhibits Akt.


delta-opioid Negative_regulation (inhibits) of Akt associated with antagonist, opioid receptor and morphine
1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.91

General Comments

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