INT317543

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1, Oprm1) signal transduction (Oprm1) intracellular (Pag1)
signal transducer activity (Oprm1)
Anatomy Link Frequency
4th ventricle 1
Pag1 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 84 100.00 Very High Very High Very High
Periaqueductal grey 18 100.00 Very High Very High Very High
analgesia 4 99.60 Very High Very High Very High
Opioid 14 97.82 Very High Very High Very High
tail-flick 5 93.92 High High
withdrawal 2 93.32 High High
Morphine 77 84.80 Quite High
Analgesic 19 64.88 Quite High
antinociception 3 62.40 Quite High
tolerance 28 22.40 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 18 100.00 Very High Very High Very High
Nociception 7 89.92 High High
Sprains And Strains 3 79.20 Quite High
Targeted Disruption 1 74.24 Quite High
Pain 3 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The icv doses of the opioid required to produce these effects affect regions with poor density of MORs such as the ventricle walls, the PAG which is responsible of MOR-mediated analgesia, and to a minor extent the floor of the 4th ventricle without reaching the spinal level [43].
PAG Positive_regulation (responsible) of MOR in 4th ventricle associated with periaqueductal grey, opioid receptor, opioid and analgesia
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.73 Pain Relevance 0.97

General Comments

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