INT31757

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 9.70
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
endothelial cells 1
MDA-MB-468 1
astrocyte 1
cortex 1
urine 1
Egf (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 4 99.74 Very High Very High Very High
Opioid 7 99.20 Very High Very High Very High
Central nervous system 15 98.48 Very High Very High Very High
Taxol 14 98.32 Very High Very High Very High
Kinase C 8 98.00 Very High Very High Very High
Morphine 4 93.44 High High
psoriasis 3 92.48 High High
abdominal pain 2 89.76 High High
opiate 2 83.56 Quite High
Endogenous opioid 1 83.12 Quite High
Disease Link Frequency Relevance Heat
Renal Cancer 18 98.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 75 98.00 Very High Very High Very High
Cancer 140 97.48 Very High Very High Very High
Pancreatic Cancer 57 97.00 Very High Very High Very High
Apoptosis 104 96.40 Very High Very High Very High
Targeted Disruption 372 96.16 Very High Very High Very High
Diabetic Foot Ulcer 1 96.04 Very High Very High Very High
Arthropathy 4 95.96 Very High Very High Very High
Injury 259 95.12 Very High Very High Very High
Metastasis 49 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since 1983, recombinant human EGF (rh-EGF) has been produced in large quantities by the recombination of the human EGF gene and expression in microorganisms.
Negative_regulation (recombination) of EGF gene
1) Confidence 0.41 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 1.02 Pain Relevance 0
We determined whether blockade of EGF-R by the tyrosine kinase inhibitor PKI 166 inhibited the growth of RCC in bone.
Spec (whether) Negative_regulation (blockade) of EGF-R associated with renal cancer
2) Confidence 0.39 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12782601 Disease Relevance 1.19 Pain Relevance 0.08
These results suggest that blockade of EGF-R signaling inhibits growth of RCC in the bone by its effect on tumor cells and tumor-associated endothelial cells.
Negative_regulation (blockade) of EGF-R in endothelial cells associated with cancer and renal cancer
3) Confidence 0.39 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12782601 Disease Relevance 0.99 Pain Relevance 0.28
We examined whether, heparin binding-epidermal growth factor-like growth factor (HB-EGF), a recently described member of the epidermal growth factor (EGF) family, might compete with an inhibitory opioid signal.
Spec (might) Negative_regulation (compete) of EGF associated with opioid
4) Confidence 0.30 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729296 Disease Relevance 0.15 Pain Relevance 1.06
We also observed a decrease in EGF-directed migration in shRNA-downregulated MDA-MB-468 cell lines.
Negative_regulation (decrease) of EGF in MDA-MB-468
5) Confidence 0.30 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2254193 Disease Relevance 0.44 Pain Relevance 0
We observed a reduction in both EGF-induced cell migration on fibronectin-coated plates in Boyden chambers (Figure 2B) and invasive activity on matrigel-coated plates (Figure 2C).
Negative_regulation (reduction) of EGF
6) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.16 Pain Relevance 0
In the present study, we detected a decrease in p-EGF receptor protein and subsequent activation of ERK signaling in the prefrontal cortex of HB-EGF KO mice (vs. control mice).
Negative_regulation (decrease) of EGF in cortex associated with targeted disruption
7) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.38 Pain Relevance 0.12
The retention or loss of the EGF receptor is suggested to facilitate alternative fate choices.
Negative_regulation (loss) of EGF
8) Confidence 0.27 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0.06 Pain Relevance 0
Simultaneous removal of EGF and FGF-2 on laminin results in astrocyte differentiation (unpublished data).
Negative_regulation (removal) of EGF in astrocyte
9) Confidence 0.27 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0.51 Pain Relevance 0
Furthermore, COX-2 expression by heparin-binding EGF-like growth factor, a member of the EGF family growth factors, was blocked by a specific EGF receptor (EGF-R) inhibitor in the rat gastric mucosa [11].
Negative_regulation (inhibitor) of EGF-R
10) Confidence 0.26 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 0.28 Pain Relevance 0.21
Furthermore, COX-2 expression by heparin-binding EGF-like growth factor, a member of the EGF family growth factors, was blocked by a specific EGF receptor (EGF-R) inhibitor in the rat gastric mucosa [11].
Negative_regulation (inhibitor) of EGF
11) Confidence 0.26 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 0.28 Pain Relevance 0.21
Circadian levels of GH and EGF, normal before therapy, were significantly decreased after therapy.
Negative_regulation (decreased) of EGF
12) Confidence 0.25 Published 1988 Journal Arch. Dermatol. Res. Section Abstract Doc Link 2900624 Disease Relevance 0.88 Pain Relevance 0.32
In contrast, iNOS, a key regulator of oxidant-induced epithelial barrier disruption, has been reportedly downregulated through an EGF-R downstream ?
Negative_regulation (downregulated) of EGF-R
13) Confidence 0.23 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 0.50 Pain Relevance 0.12
Nude mice were treated with a novel orally given EGF-R tyrosine kinase inhibitor, PKI 166 (4-(R)-phenethylamino-6-(hydroxyl)phenyl-7H-pyrrolo [2.3-d]-pyrimidine), 7 days after orthotopic injection of L3.6pl human pancreatic cancer cells.
Negative_regulation (inhibitor) of EGF-R associated with pancreatic cancer
14) Confidence 0.17 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.18 Pain Relevance 0.24
EGF receptor tyrosine kinase inhibitors.
Negative_regulation (inhibitors) of EGF
15) Confidence 0.13 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.86 Pain Relevance 0
CONCLUSIONS: Treatment of PBS/IC patients with CyA resulted in significantly decreased urinary levels of EGF.
Negative_regulation (decreased) of EGF
16) Confidence 0.10 Published 2008 Journal Urology Section Body Doc Link 18387391 Disease Relevance 0.05 Pain Relevance 0
In the CyA group, post-treatment urinary EGF levels were significantly reduced (from 35 +/- 15.8 to 28.3 +/- 17.9 ng/mg creatinine; P <0.034), whereas the urinary IL-6 levels were not affected by CyA or PPS treatment in the whole group.
Negative_regulation (reduced) of EGF
17) Confidence 0.08 Published 2008 Journal Urology Section Body Doc Link 18387391 Disease Relevance 0.07 Pain Relevance 0
Further, the amounts of urine EGF and IGF1 were also elevated in IC patients as compared to patients with bacterial cystitis, and urine IGFBP3 levels were significantly elevated when expressed per milligram of urine creatinine.
Negative_regulation (amounts) of EGF in urine
18) Confidence 0.06 Published 1997 Journal J. Urol. Section Body Doc Link 9334654 Disease Relevance 0.07 Pain Relevance 0
3-OH flavone inhibition of epidermal growth factor-induced proliferaton through blocking prostaglandin E2 production.
Negative_regulation (inhibition) of epidermal growth factor associated with cox2
19) Confidence 0.05 Published 2004 Journal Int. J. Cancer Section Title Doc Link 14696113 Disease Relevance 0.15 Pain Relevance 0.30
EGF induced EGFR downregulation, an ESCRT-I dependent process, was attenuated in HIV-1 Gag expressing cells [14].
Negative_regulation (downregulation) of EGF associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.04 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.49 Pain Relevance 0

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