INT31758

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Context Info
Confidence 0.66
First Reported 1988
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 19.42
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
urine 5
lymph node 2
fibroblasts 2
blood 2
endothelial cells 2
Egf (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 198 99.62 Very High Very High Very High
COX2 2 99.46 Very High Very High Very High
agonist 2 99.36 Very High Very High Very High
cytokine 167 99.20 Very High Very High Very High
Arthritis 96 96.84 Very High Very High Very High
Somatostatin 6 95.24 Very High Very High Very High
Taxol 8 95.08 Very High Very High Very High
Inflammation 121 94.96 High High
psoriasis 6 88.12 High High
chemokine 48 86.80 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 202 99.62 Very High Very High Very High
Cancer 603 98.88 Very High Very High Very High
Wound Healing 72 98.64 Very High Very High Very High
Apoptosis 173 98.24 Very High Very High Very High
Adenocarcinoma 51 98.16 Very High Very High Very High
Interstitial Cystitis 25 97.44 Very High Very High Very High
Metastasis 70 97.12 Very High Very High Very High
Prostate Cancer 34 97.04 Very High Very High Very High
Ulcers 35 96.88 Very High Very High Very High
Arthritis 93 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study revealed that gastric ulceration in mice was associated with a marked increase in the mucosal EGF level.
Positive_regulation (increase) of EGF
1) Confidence 0.66 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.48 Pain Relevance 0.07
Immunohistochemical analysis revealed that tumor cells and tumor-associated endothelial cells in control mice expressed activated EGF-R.
Positive_regulation (activated) of EGF-R in endothelial cells associated with cancer
2) Confidence 0.63 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12782601 Disease Relevance 1.26 Pain Relevance 0.20
1 in the EGF-treated group was increased.
Positive_regulation (increased) of EGF-treated
3) Confidence 0.48 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2844601 Disease Relevance 0.89 Pain Relevance 0.08
OBJECTIVE: The objectives of the study are to identify subtype of the 5-HT(2) receptor involved, to establish whether ERK(1/2) phosphorylation is a result of 5-HT(2)-mediated transactivation of epidermal growth factor (EGF) receptors (EGFRs), and to determine signaling pathways up- and downstream of ERK(1/2).
Positive_regulation (transactivation) of EGF
4) Confidence 0.45 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
Phosphorylation of ERK(1/2) and EGFRs was abolished by AG 1478, an inhibitor of EGFR tyrosine kinases, and GM 6001, an inhibitor of Zn-dependent metalloproteinases, suggesting growth factor "shedding" and transactivation of EGFRs.
Positive_regulation (transactivation) of EGF
5) Confidence 0.45 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: The objectives of the study are to identify subtype of the 5-HT(2) receptor involved, to establish whether ERK(1/2) phosphorylation is a result of 5-HT(2)-mediated transactivation of epidermal growth factor (EGF) receptors (EGFRs), and to determine signaling pathways up- and downstream of ERK(1/2).
Positive_regulation (transactivation) of EGF
6) Confidence 0.45 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: The objectives of the study are to identify subtype of the 5-HT(2) receptor involved, to establish whether ERK(1/2) phosphorylation is a result of 5-HT(2)-mediated transactivation of epidermal growth factor (EGF) receptors (EGFRs), and to determine signaling pathways up- and downstream of ERK(1/2).
Positive_regulation (transactivation) of epidermal growth factor
7) Confidence 0.45 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
These effects are executed through a heterotrimeric G protein-coupled receptor, which mediates Ang II transactivated epidermal growth factor (EGF)-induced activation of MEK (MAPK kinase 1) and ERK [12].
Positive_regulation (activation) of epidermal growth factor
8) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.65 Pain Relevance 0
These effects are executed through a heterotrimeric G protein-coupled receptor, which mediates Ang II transactivated epidermal growth factor (EGF)-induced activation of MEK (MAPK kinase 1) and ERK [12].
Positive_regulation (activation) of EGF
9) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.59 Pain Relevance 0
In our study, phosphorylations of EGFR Tyr1173 and HER2 Tyr1248 (Figure 3A), EGFR Tyr1173 (Figure 3B), and Tyr1068 (data not shown) were reduced in S100A7-downregulated cells as compared to empty vector-transfected cell lines following treatment with increasing concentrations of EGF.
Positive_regulation (increasing) of EGF
10) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.17 Pain Relevance 0
Recently, it has been shown that S100A7 is associated with an increase in EGF mRNA levels [8].
Positive_regulation (increase) of EGF mRNA
11) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.55 Pain Relevance 0
Consistent with our results, a previous study (using the same line of mice with loxP-flanked Hb-egf cDNA) demonstrated that a mutation of the Hb-egf gene was associated with decreases in the activation of EGF receptor and ERK [49].
Positive_regulation (activation) of EGF
12) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.28 Pain Relevance 0.10
Validation of the platelet gel comprised measurement of the growth factors platelet-derived growth factor AB (PDGF AB) and epidermal growth factor (EGF), as well as the thrombocyte and leukocyte counts.
Positive_regulation (measurement) of epidermal growth factor in platelet
13) Confidence 0.30 Published 2008 Journal J Extra Corpor Technol Section Abstract Doc Link 18853833 Disease Relevance 0.62 Pain Relevance 0
Furthermore, the upregulation of EGF and the EGF receptor is even more frequent in pancreatic adenocarcinoma with lymph node and distant metastases [21,22].
Positive_regulation (upregulation) of EGF in lymph node associated with adenocarcinoma and metastasis
14) Confidence 0.27 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.08 Pain Relevance 0
These effects are executed through a heterotrimeric G protein-coupled receptor, which mediates Ang II transactivated epidermal growth factor (EGF)-induced activation of MEK (MAPK kinase 1) and ERK [12].
Positive_regulation (mediates) of EGF
15) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.76 Pain Relevance 0
These effects are executed through a heterotrimeric G protein-coupled receptor, which mediates Ang II transactivated epidermal growth factor (EGF)-induced activation of MEK (MAPK kinase 1) and ERK [12].
Positive_regulation (mediates) of epidermal growth factor
16) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.76 Pain Relevance 0
Moreover, STAT-3 activation in response to PDGF or EGF, a prosurvival signaling event for mesenchymal cells, is significantly greater in STAT-1-/- mouse lung fibroblasts compared to STAT-1+/+ fibroblasts.
Positive_regulation (activation) of EGF in fibroblasts
17) Confidence 0.25 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.63 Pain Relevance 0.12
IL-2, IL-4, IL-13, IL-17, IL-15, basic fibroblast growth factor and epidermal growth factor) were significantly elevated in these patients within 3 months after symptom onset, as compared with early arthritis patients who did not develop RA.
Positive_regulation (elevated) of epidermal growth factor in fibroblast associated with rheumatoid arthritis and arthritis
18) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175027 Disease Relevance 1.39 Pain Relevance 0.96
Patients with early RA had significantly elevated synovial levels of IL-2, IL-4, IL-13, IL-17, EGF and bFGF when compared with patients with established RA (Figs 1 and 2, and Table 2).
Positive_regulation (elevated) of EGF associated with rheumatoid arthritis
19) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 2.22 Pain Relevance 0.95
Microarray results from cells invading matrigel are consist with above suggestion, since high fat diet stimulated the gene expression of numerous proangiogenic factors like Vegf, Egf, Fgf1, Hbegf, Pdgfa, Fgf18.
Positive_regulation (stimulated) of Egf in fat
20) Confidence 0.23 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.44 Pain Relevance 0.05

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