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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.24
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
plasma 2
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 9 99.38 Very High Very High Very High
cytokine 3 93.84 High High
Multiple sclerosis 26 84.40 Quite High
Inflammation 37 81.20 Quite High
depression 1 73.68 Quite High
Intracerebroventricular 8 72.60 Quite High
Hippocampus 10 70.20 Quite High
Spinal cord 30 39.60 Quite Low
Neuropeptide 1 29.84 Quite Low
noradrenaline 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 132 99.90 Very High Very High Very High
Disease 23 97.76 Very High Very High Very High
Stress 170 89.92 High High
Apoptosis 2 84.76 Quite High
INFLAMMATION 40 81.20 Quite High
Recurrence 5 79.60 Quite High
Depression 1 73.68 Quite High
Cushing's Syndrome /


2 71.96 Quite High
Endometriosis (extended) 11 71.84 Quite High
Sprains And Strains 2 55.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immediate-early gene mapping studies have indicated that the LSV and MeA are key areas gating afferent activation of the PVN and which contribute to adaptive changes in PVN activation and HPA responsiveness.
Positive_regulation (activation) of Gene_expression (responsiveness) of HPA associated with amygdala
1) Confidence 0.14 Published 2010 Journal Brain Research Section Body Doc Link PMC2994639 Disease Relevance 0.06 Pain Relevance 0.15
Although it is difficult to compare among studies the absolute plasma levels of estradiol exhibited by women before being exposed to acute stressors because different measurement methods were used, it is worth mentioning that, in all the studies analyzed in this section, independently of the replacement regimen followed, the HPA axis always displayed a positive response when plasma levels of estradiol were relatively low (?
Positive_regulation (response) of Gene_expression (axis) of HPA in plasma
2) Confidence 0.08 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2890612 Disease Relevance 0.32 Pain Relevance 0.07
Besides, it has been established that in EAE the HPA axis is activated in during clinical exacerbations, and that levels of corticosterone decrease as clinical signs remit [55].
Positive_regulation (activated) of Gene_expression (axis) of HPA associated with multiple sclerosis
3) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.72 Pain Relevance 0.37

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