INT31760

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Context Info
Confidence 0.23
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.84
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Itpr3) endoplasmic reticulum (Itpr3) nucleolus (Itpr3)
nucleus (Itpr3) transmembrane transport (Itpr3) cytoplasm (Itpr3)
Anatomy Link Frequency
neurons 1
CHO 1
Itpr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 1 99.76 Very High Very High Very High
long-term potentiation 68 99.08 Very High Very High Very High
spinal dorsal horn 13 94.04 High High
Opioid receptor 1 2 90.24 High High
narcan 2 87.76 High High
withdrawal 3 85.60 High High
Opioid 2 85.16 High High
Kinase C 14 84.36 Quite High
opiate 1 75.68 Quite High
antagonist 19 75.40 Quite High
Disease Link Frequency Relevance Heat
Li-fraumeni Syndrome 4 99.56 Very High Very High Very High
Urological Neuroanatomy 2 97.84 Very High Very High Very High
Opiate Addiction 2 85.60 High High
Low Back Pain 5 66.28 Quite High
Ganglion Cysts 31 55.88 Quite High
Pain 32 50.00 Quite Low
Nociception 11 50.00 Quite Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In their study, blockade of IP3R converted LFS-induced LTP into LTD in lamina I spino-PAG neurons, which is similar to our positive control in the hippocampal slices (Fig. 4B).
Negative_regulation (blockade) of IP3R in neurons associated with li-fraumeni syndrome, urological neuroanatomy and long-term potentiation
1) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826347 Disease Relevance 0.84 Pain Relevance 1.02
Isoproterenol-induced IP3 formation was blocked by propranolol.
Negative_regulation (blocked) of IP3
2) Confidence 0.20 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 2900837 Disease Relevance 0 Pain Relevance 0.03
In contrast, the blockade of the IP3 receptor with 2-aminoethoxydiphenylborane (2-APB, 100 ?
Negative_regulation (blockade) of IP3
3) Confidence 0.14 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.18
We assumed IP3 binding induced an IP3R conformational change that blocked additional IP3 binding and exposed three calcium binding sites.
Negative_regulation (blocked) of IP3
4) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0 Pain Relevance 0
Morphine (1 microM) reduced both forskolin-stimulated cAMP levels and IP3 levels by 20 +/- 5 and 34 +/- 8% respectively in COS and CHO cell cultures expressing the cloned rat mu receptor cDNA.
Negative_regulation (reduced) of IP3 in CHO associated with morphine
5) Confidence 0.08 Published 1994 Journal Neuroreport Section Abstract Doc Link 8003685 Disease Relevance 0 Pain Relevance 0.38

General Comments

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