INT31761

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 5.95
Pain Relevance 8.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Itpr3) endoplasmic reticulum (Itpr3) nucleolus (Itpr3)
nucleus (Itpr3) transmembrane transport (Itpr3) cytoplasm (Itpr3)
Anatomy Link Frequency
smooth muscle 2
blood 1
outflow 1
neuronal 1
spikes 1
Itpr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 205 100.00 Very High Very High Very High
Spinal cord 114 100.00 Very High Very High Very High
nMDA receptor 34 100.00 Very High Very High Very High
agonist 88 99.88 Very High Very High Very High
tetrodotoxin 38 99.78 Very High Very High Very High
Kappa opioid receptor 16 99.72 Very High Very High Very High
Action potential 25 99.24 Very High Very High Very High
tolerance 7 99.18 Very High Very High Very High
Potency 7 98.84 Very High Very High Very High
Neuropeptide 11 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 24 99.44 Very High Very High Very High
Nociception 34 99.08 Very High Very High Very High
Hypertrophy 24 97.68 Very High Very High Very High
INFLAMMATION 44 97.64 Very High Very High Very High
Spinal Cord Injury 181 92.72 High High
Injury 108 89.92 High High
Brain Injury 3 89.20 High High
Bordatella Infection 8 84.68 Quite High
Hypertension 20 81.00 Quite High
Diabetes Mellitus 29 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus it appears that sustained afferent nociceptive input induced by FCA injection increased the accumulation of cGMP, insP3 and insP3R density in the spinal cord through increased neuronal activities of functional receptors coupled to major classes of chemical mediators of nociception including neuropeptides and excitatory aminoacids.
Positive_regulation (accumulation) of insP3 in neuronal associated with nociception, neuropeptide and spinal cord
1) Confidence 0.58 Published 1994 Journal Pain Section Abstract Doc Link 7970840 Disease Relevance 0.52 Pain Relevance 0.30
Changes in insP3 accumulation in the lumbosacral cord following FCA injection were significantly correlated with changes in insP3R density.
Positive_regulation (accumulation) of insP3
2) Confidence 0.58 Published 1994 Journal Pain Section Abstract Doc Link 7970840 Disease Relevance 0.48 Pain Relevance 0.28
However, cGMP and insP3 contents were significantly increased in the left longitudinal half of the lumbar enlargement ipsilateral to the injected paw on day 21 following FCA treatment, but not in the sham-treated time-matched controls.
Neg (not) Positive_regulation (increased) of insP3 in paw
3) Confidence 0.58 Published 1994 Journal Pain Section Abstract Doc Link 7970840 Disease Relevance 0.41 Pain Relevance 0.28
InsP3 accumulation was significantly increased on days 14, 21 and 42 following FCA injection relative to sham-treated time-matched controls.
Positive_regulation (accumulation) of InsP3
4) Confidence 0.51 Published 1994 Journal Pain Section Abstract Doc Link 7970840 Disease Relevance 0.36 Pain Relevance 0.26
And IP3 content in the spinal cord also increased dramatically within 30 min, but decreased rapidly to control level 45 min after EA stimulation.
Positive_regulation (increased) of IP3 in spinal cord associated with electroacupuncture and spinal cord
5) Confidence 0.50 Published 1994 Journal Chin. Med. J. Section Abstract Doc Link 7956484 Disease Relevance 0 Pain Relevance 1.17
With [3H]insP3 as a ligand, Scatchard (Rosenthal) analyses of the concentration-dependent saturation curves showed that the densities (Bmax) of insP3 receptors (insP3R) were significantly increased throughout the time course of adjuvant-induced peripheral inflammation.
Positive_regulation (increased) of insP3 associated with inflammation
6) Confidence 0.42 Published 1994 Journal Pain Section Abstract Doc Link 7970840 Disease Relevance 0.48 Pain Relevance 0.31
CaM kinase related genes (Camk2g and Camk2b, profile 9) as well as one IP3 receptor (Itpr3, profile 7) and the Ca2+ binding protein caldendrin (Cabp1, profile 11) are up-regulated.
Positive_regulation (regulated) of IP3 receptor
7) Confidence 0.41 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.24 Pain Relevance 0.25
Both IP3 and [Ca2+]i were increased following kappa-opioid receptor stimulation.
Positive_regulation (increased) of IP3 associated with kappa opioid receptor
8) Confidence 0.41 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8836621 Disease Relevance 0 Pain Relevance 0.41
Acetylcholine (100 microM) and muscarine (100 microM) increased IP3 outflow by 40 and 42%, respectively.
Positive_regulation (increased) of IP3 in outflow
9) Confidence 0.40 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294918 Disease Relevance 0 Pain Relevance 0.17
Local infusion of carbachol for 60 min caused a significant concentration-related increase in extracellular IP3 levels (0, 24, and 57% at 1, 50, and 100 microM, respectively).
Positive_regulation (increase) of IP3
10) Confidence 0.40 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294918 Disease Relevance 0 Pain Relevance 0.16
Both substances caused an increase in the intracellular concentration of IP3.
Positive_regulation (increase) of IP3
11) Confidence 0.36 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9726662 Disease Relevance 0 Pain Relevance 0
Extreme increase of the thalamic pLT and IP3 levels in traumatized animals together with increased blood-brain barrier permeability were found.
Positive_regulation (increase) of IP3 in blood
12) Confidence 0.36 Published 1994 Journal Vojnosanit Pregl Section Abstract Doc Link 8560818 Disease Relevance 0.23 Pain Relevance 0.55
The results suggest that the effects of these sigma receptor ligands on contractility and spontaneous contractions are mediated by activation of phospholipase C and elevation of intracellular IP3 level.
Positive_regulation (elevation) of IP3
13) Confidence 0.34 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9726662 Disease Relevance 0 Pain Relevance 0
The present study showed for the first time that, upon the development of tolerance to a kappa-opioid receptor agonist, the responses of IP3 and [Ca2+]i to kappa-opioid receptor stimulation were abolished.
Positive_regulation (responses) of IP3 associated with agonist, kappa opioid receptor and tolerance
14) Confidence 0.30 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8836621 Disease Relevance 0 Pain Relevance 0.64
PbTx-3 caused a tetrodotoxin-sensitive increase in intracellular IP3 mass levels, dependent on extra-cellular Na+.
Positive_regulation (increase) of IP3 associated with tetrodotoxin
15) Confidence 0.29 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18276006 Disease Relevance 0 Pain Relevance 0.28
Sodium-dependent action potentials induced by brevetoxin-3 trigger both IP3 increase and intracellular Ca2+ release in rat skeletal myotubes.
Positive_regulation (increase) of IP3 in myotubes associated with action potential
16) Confidence 0.29 Published 2008 Journal Cell Calcium Section Title Doc Link 18276006 Disease Relevance 0 Pain Relevance 0.24
A similar increase in IP3 mass was induced by high K+ depolarization but no action potential trains (nor calcium signals) were elicited by prolonged depolarization under current clamp conditions.
Positive_regulation (increase) of IP3 associated with action potential
17) Confidence 0.29 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18276006 Disease Relevance 0 Pain Relevance 0.28
The increase in IP3 mass induced by either PbTx-3 or K+ was also detected in Ca2+-free medium.
Positive_regulation (increase) of IP3
18) Confidence 0.29 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18276006 Disease Relevance 0 Pain Relevance 0.27
Isoproterenol-induced IP3 formation was blocked by propranolol.
Positive_regulation (Isoproterenol-induced) of IP3
19) Confidence 0.23 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 2900837 Disease Relevance 0 Pain Relevance 0.03
Sensitivity analysis was then used, over the family of parameter sets, to estimate which parameters were critical globally and key to specific model outputs (cytosolic calcium concentration, the fraction of gated IP3R channels and Gq-protein activation).
Positive_regulation (activation) of IP3R
20) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.17 Pain Relevance 0.20

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