INT317635

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Drd1a, Gtf3a) intracellular (Drd1a, Gtf3a) RNA binding (Gtf3a)
endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) DNA binding (Gtf3a)
Anatomy Link Frequency
neurons 3
Drd1a (Rattus norvegicus)
Gtf3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 1 98.32 Very High Very High Very High
cerebral cortex 37 94.88 High High
dopamine receptor 12 90.72 High High
addiction 2 89.20 High High
Dopamine 39 84.72 Quite High
Neurotransmitter 11 82.64 Quite High
long-term potentiation 1 45.08 Quite Low
Eae 4 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 11 92.16 High High
Drug Dependence 2 89.20 High High
Diabetes Mellitus 90 80.56 Quite High
Stress 9 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low
Cerebellar Diseases 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dudman et al [64] reported that D2 receptors activate the cAMP response element-binding protein in neurons and D1 receptor stimulation leads to phosphorylation of the transcription factor Ca2+ and CREB in the nucleus by means of NMDA receptor-mediated Ca 2+ signaling.
Positive_regulation (stimulation) of D1 receptor in neurons Positive_regulation (leads) of Phosphorylation (phosphorylation) of factor in neurons associated with nmda receptor
1) Confidence 0.01 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.53 Pain Relevance 0.43

General Comments

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