INT317636

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) DNA binding (Creb1)
cell-cell signaling (Hmmr) cytoplasm (Hmmr) nucleolus (Creb1)
Anatomy Link Frequency
neurons 2
Creb1 (Rattus norvegicus)
Hmmr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 1 100.00 Very High Very High Very High
cerebral cortex 37 97.00 Very High Very High Very High
dopamine receptor 12 95.84 Very High Very High Very High
addiction 2 91.32 High High
Neurotransmitter 11 87.76 High High
Dopamine 39 86.84 High High
long-term potentiation 1 47.20 Quite Low
Eae 4 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 11 94.28 High High
Drug Dependence 2 91.32 High High
Diabetes Mellitus 90 82.68 Quite High
Stress 9 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low
Cerebellar Diseases 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dudman et al [64] reported that D2 receptors activate the cAMP response element-binding protein in neurons and D1 receptor stimulation leads to phosphorylation of the transcription factor Ca2+ and CREB in the nucleus by means of NMDA receptor-mediated Ca 2+ signaling.
cAMP response element-binding protein Positive_regulation (leads) of Phosphorylation (phosphorylation) of NMDA receptor-mediated in neurons associated with nmda receptor
1) Confidence 0.04 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.55 Pain Relevance 0.45

General Comments

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