INT317638

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) intracellular (Drd1a) carbohydrate metabolic process (Ins1)
signal transducer activity (Drd1a) cytoplasm (Ins1) extracellular space (Ins1)
Anatomy Link Frequency
cerebellum 2
Ins1 (Rattus norvegicus)
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 39 100.00 Very High Very High Very High
Eae 4 96.76 Very High Very High Very High
antagonist 2 94.60 High High
dopamine receptor 12 86.88 High High
cerebral cortex 37 56.80 Quite High
Thalamus 2 50.20 Quite High
Neurotransmitter 11 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 1 100.00 Very High Very High Very High
Diabetes Mellitus 90 98.44 Very High Very High Very High
Cerebellar Diseases 3 90.64 High High
Schizophrenia 1 67.28 Quite High
Cognitive Disorder 11 66.16 Quite High
Disease 3 39.04 Quite Low
Congenital Anomalies 2 36.88 Quite Low
Stress 9 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study, curcumin and insulin increased the dopamine D1 receptor expression levels in the cerebellum, which suggests that the curcumin supplementation influenced the functional regulation of these receptors to maintain normal dopaminergic function and this might also be involved as a mechanism of preventing cerebellar dysfunctions.
insulin Positive_regulation (increased) of Gene_expression (expression) of dopamine D1 receptor in cerebellum associated with cerebellar diseases, dopamine and hyperinsulinism
1) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.86 Pain Relevance 0.59

General Comments

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