INT317683

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Context Info
Confidence 0.76
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 5.54
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabra3) plasma membrane (Gabra3)
Anatomy Link Frequency
neurons 1
hippocampus 1
Gabra3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 224 99.92 Very High Very High Very High
monoamine 70 99.84 Very High Very High Very High
depression 210 96.36 Very High Very High Very High
agonist 126 95.12 Very High Very High Very High
antidepressant 140 91.12 High High
GABAergic 42 80.12 Quite High
Eae 14 80.00 Quite High
gABA 98 75.64 Quite High
fluoxetine 14 66.48 Quite High
GABA receptor 14 56.84 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 658 99.50 Very High Very High Very High
Manic Depressive Disorder 28 98.60 Very High Very High Very High
Targeted Disruption 42 98.44 Very High Very High Very High
Depression 266 96.36 Very High Very High Very High
Affective Disorder 56 95.00 High High
Depressive Disorder 28 70.88 Quite High
Autism 14 12.32 Low Low
Anxiety Disorder 28 5.00 Very Low Very Low Very Low
Stress 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering the strain-specific differences in Gabra3 expression and the role that the ?
Gene_expression (expression) of Gabra3 associated with sprains and strains
1) Confidence 0.76 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.44 Pain Relevance 0.15
3 subunit regulates TST performance, B6 mice, which express Gabra3, would be expected to respond to the drug, while NZB mice, which lack Gabra3 expression, would not respond.
Gene_expression (express) of Gabra3
2) Confidence 0.76 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.35 Pain Relevance 0.26
Expression of Gabra3, which encodes the GABAA receptor ?
Gene_expression (Expression) of Gabra3
3) Confidence 0.76 Published 2010 Journal Mamm Genome Section Abstract Doc Link PMC2890984 Disease Relevance 0.44 Pain Relevance 0.14
RT-PCR analysis of these four genes in hippocampal tissue from B6, NZB, and R3 mice indicated that expression of Gabra3 was significantly reduced in NZB compared to B6 and R3.
Gene_expression (expression) of Gabra3
4) Confidence 0.76 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.41 Pain Relevance 0.21
As Gabra3 is preferentially expressed by monoaminergic neurons, it may represent a prime therapeutic target in the treatment of depression.


Gene_expression (expressed) of Gabra3 in neurons associated with depression and monoamine
5) Confidence 0.76 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.29 Pain Relevance 0.56
It is likely that this unique genetic background impacted the phenotypic expression of the knockout, just as the B6 and R3 mice in this study had divergent TST profiles despite expressing similar levels of Gabra3.
Gene_expression (expressing) of Gabra3 associated with targeted disruption
6) Confidence 0.76 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.44 Pain Relevance 0.05
As predicted by the microarray data, Gabra3 expression was high in B6 and R3 mice but absent in NZB mice.
Neg (absent) Gene_expression (expression) of Gabra3
7) Confidence 0.76 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.50 Pain Relevance 0.33
3 subunit regulates TST performance, B6 mice, which express Gabra3, would be expected to respond to the drug, while NZB mice, which lack Gabra3 expression, would not respond.
Gene_expression (expression) of Gabra3
8) Confidence 0.66 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.33 Pain Relevance 0.27
One gene within the NZBF2-specific MMUX QTL, Gabra3 (GABAA receptor ?
Gene_expression (receptor) of Gabra3
9) Confidence 0.66 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.39 Pain Relevance 0.31
The Gabra3 5?
Gene_expression (The) of Gabra3
10) Confidence 0.66 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.56 Pain Relevance 0.32
As deletion of these GA repeats results in a significant reduction in Gabra3 expression in vitro, it is possible that NZB mice carry a mutation that disrupts the promoter region.
Gene_expression (expression) of Gabra3
11) Confidence 0.59 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.33 Pain Relevance 0.11
UTR, coding regions, and intron/exon splice sites in the three parental strains in order to identify structural variants that might cause the loss of Gabra3 expression in NZB hippocampus.
Gene_expression (expression) of Gabra3 in hippocampus associated with hippocampus and sprains and strains
12) Confidence 0.59 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.33 Pain Relevance 0.13
However, the mouse Gabra3 promoter contains a region of 55 GA repeats that have been shown to have an enhancer function in Gabra3 expression (Mu and Burt 1999).
Gene_expression (expression) of Gabra3
13) Confidence 0.59 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.33 Pain Relevance 0.12
We compared expression of the MMUX GABAA receptor subunit genes Gabra3, Gabre, and Gabrq, in hippocampal tissue from the NZB, B6, and R3 strains.
Gene_expression (expression) of Gabra3 associated with sprains and strains
14) Confidence 0.26 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.41 Pain Relevance 0.11

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