INT317705

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gad2, Gabrg1) transport (Gabrg1) lyase activity (Gad2)
Golgi apparatus (Gad2) cytoplasm (Gad2)
Gad2 (Mus musculus)
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 7 100.00 Very High Very High Very High
depression 15 99.24 Very High Very High Very High
agonist 9 98.54 Very High Very High Very High
GABA receptor 1 92.08 High High
antidepressant 10 88.40 High High
monoamine 5 87.84 High High
GABAergic 3 86.40 High High
Hippocampus 16 79.76 Quite High
fluoxetine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 19 99.64 Very High Very High Very High
Affective Disorder 4 79.60 Quite High
Sprains And Strains 47 46.12 Quite Low
Targeted Disruption 3 39.32 Quite Low
Depressive Disorder 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Autism 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In animal models of depression, several GABAA agonists have been shown to reduce putative depressive symptoms, and deletion of Gad65, which regulates GABA synthesis, affects multiple depression-like behaviors (Cryan et al. 2005; Stork et al. 2000; Tunnicliff et al. 1973).
Gad65 Regulation (regulates) of Gene_expression (synthesis) of GABA associated with gaba, depression and agonist
1) Confidence 0.28 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.53 Pain Relevance 0.80

General Comments

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