INT31774

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Context Info
Confidence 0.44
First Reported 1988
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 67
Total Number 76
Disease Relevance 14.52
Pain Relevance 71.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Vta1)
Anatomy Link Frequency
nucleus accumbens 11
ventral 4
dopamine neurons 4
DA neurons 3
brain 2
Vta1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 1611 100.00 Very High Very High Very High
Dopamine 1025 100.00 Very High Very High Very High
depression 831 100.00 Very High Very High Very High
Nucleus accumbens 234 100.00 Very High Very High Very High
gABA 191 100.00 Very High Very High Very High
Morphine 167 100.00 Very High Very High Very High
Glutamate 89 100.00 Very High Very High Very High
amygdala 63 100.00 Very High Very High Very High
opioid receptor 46 100.00 Very High Very High Very High
Hippocampus 44 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 850 100.00 Very High Very High Very High
Li-fraumeni Syndrome 144 99.98 Very High Very High Very High
Stress 91 99.24 Very High Very High Very High
Drug Dependence 91 98.96 Very High Very High Very High
Urological Neuroanatomy 65 98.80 Very High Very High Very High
Cognitive Disorder 32 98.80 Very High Very High Very High
Sprains And Strains 17 98.36 Very High Very High Very High
Herpes Simplex Virus 1 97.42 Very High Very High Very High
Neuropathic Pain 4 97.28 Very High Very High Very High
Hypoalagesia 3 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that most of the forebrain structures known to receive neuronal projections from the VTA, including prefrontal cortex, nucleus accumbens, globus pallidus and caudate putaman, were enhanced at 24 h after injection of MnCl(2) into the ipsilateral VTA, and anesthesia seemed have little effects on the amount of Mn(2+)being transported from the VTA to these structures.
Positive_regulation (transported) of VTA in prefrontal associated with nucleus accumbens, ventral tegmentum and anesthesia
1) Confidence 0.44 Published 2009 Journal Magn Reson Imaging Section Abstract Doc Link 18786796 Disease Relevance 0.06 Pain Relevance 0.49
The results showed that most of the forebrain structures known to receive neuronal projections from the VTA, including prefrontal cortex, nucleus accumbens, globus pallidus and caudate putaman, were enhanced at 24 h after injection of MnCl(2) into the ipsilateral VTA, and anesthesia seemed have little effects on the amount of Mn(2+)being transported from the VTA to these structures.
Positive_regulation (enhanced) of VTA in prefrontal associated with nucleus accumbens, ventral tegmentum and anesthesia
2) Confidence 0.44 Published 2009 Journal Magn Reson Imaging Section Abstract Doc Link 18786796 Disease Relevance 0.07 Pain Relevance 0.54
In the present study, we tested the hypothesis that ingestion of amniotic fluid enhances the facilitative effect of opioid activity (unilateral morphine injection) in the VTA on the rate of onset of maternal behavior.
Positive_regulation (enhances) of VTA in amniotic fluid associated with ventral tegmentum, opioid and morphine
3) Confidence 0.43 Published 2009 Journal Brain Res. Section Abstract Doc Link 19401160 Disease Relevance 0.28 Pain Relevance 1.46
Injection of the selective DA uptake blocker GBR 12935 (15 mg/kg i.p.) increased DA, as well as NE and, to a lesser extent, 5-HT in the VTA; it increased DA more than 5-HT in the NACC.
Positive_regulation (increased) of VTA in NACC associated with nucleus accumbens, ventral tegmentum and dopamine
4) Confidence 0.41 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9438681 Disease Relevance 0 Pain Relevance 1.16
The selective NE uptake blocker desipramine (10 mg/kg i.p.) increased NE but also 5-HT in the VTA and NACC; the DA level was persistently enhanced in the VTA, whereas in the NACC it initially rose and then fell below baseline value.
Positive_regulation (increased) of VTA in NACC associated with nucleus accumbens, ventral tegmentum, dopamine and desipramine
5) Confidence 0.41 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9438681 Disease Relevance 0 Pain Relevance 1.25
The selective NE uptake blocker desipramine (10 mg/kg i.p.) increased NE but also 5-HT in the VTA and NACC; the DA level was persistently enhanced in the VTA, whereas in the NACC it initially rose and then fell below baseline value.
Positive_regulation (enhanced) of VTA in NACC associated with nucleus accumbens, ventral tegmentum, dopamine and desipramine
6) Confidence 0.41 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9438681 Disease Relevance 0 Pain Relevance 1.24
These experiments indicate that the depressor responses elicited from activation of the VTA are mediated in part by a pathway to a cardiovascular depressor area located in the PAGvl.
Positive_regulation (activation) of VTA associated with ventral tegmentum
7) Confidence 0.41 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10848534 Disease Relevance 0.16 Pain Relevance 0.81
Bilateral injections of 4% lidocaine (n = 4) or 10 mM cobalt chloride (n = 5) into the PAGvl region attenuated the depressor responses elicited by stimulation of the VTA by approximately 50%.
Positive_regulation (stimulation) of VTA associated with ventral tegmentum and lidocaine
8) Confidence 0.41 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10848534 Disease Relevance 0.17 Pain Relevance 0.93
During deprived SWS, there was a direct correlation between increased VTA GABA neuron slowing and increased delta wave power.
Positive_regulation (increased) of VTA in neuron associated with ventral tegmentum and gaba
9) Confidence 0.41 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11222665 Disease Relevance 0.07 Pain Relevance 0.94
Bilateral microinjections of 1 microl of 4% lidocaine in the medial forebrain bundle (n = 6) and in the periventricular fibers of the midbrain (n = 5) did not attenuate the depressor response from stimulation of the VTA.
Positive_regulation (stimulation) of VTA in midbrain associated with ventral tegmentum, midbrain and lidocaine
10) Confidence 0.41 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10848534 Disease Relevance 0.13 Pain Relevance 0.91
The rewarding effects are associated with the activation of mu receptors in the VTA, whereas aversive effects are associated with the activation of kappa receptors in the VTA and its limbic-cortical terminal regions.
Positive_regulation (activation) of VTA associated with ventral tegmentum
11) Confidence 0.41 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093731 Disease Relevance 0 Pain Relevance 0.65
The rewarding effects are associated with the activation of mu receptors in the VTA, whereas aversive effects are associated with the activation of kappa receptors in the VTA and its limbic-cortical terminal regions.
Positive_regulation (activation) of VTA associated with ventral tegmentum
12) Confidence 0.41 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093731 Disease Relevance 0 Pain Relevance 0.77
Opiate activation of mu-opioid receptors (muORs) in the ventral tegmental area (VTA) modulates gamma-aminobutyric acid (GABA) neurotransmission within the mesocorticolimbic dopamine (DA) reward system.
Positive_regulation (activation) of VTA in ventral associated with ventral tegmentum, dopamine, gaba, mu opioid receptor and opiate
13) Confidence 0.40 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16814775 Disease Relevance 0 Pain Relevance 0.87
The increase in food intake after DAMGO injection into the VTA was decreased following injection of naltrexone into the NTS.
Positive_regulation (increase) of VTA
14) Confidence 0.40 Published 2009 Journal Appetite Section Abstract Doc Link 19748538 Disease Relevance 0 Pain Relevance 0.36
The existence of a tonic GABAB receptor-mediated inhibition of somatodendritic DA release has been suggested by the evidence that, in vivo, the administration of CGP55845A into the ventral tegmental area produces a dose-dependent increase in VTA dopamine levels [49].
Positive_regulation (increase) of VTA in ventral associated with ventral tegmentum and dopamine
15) Confidence 0.40 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.83
In addition, under the condition of the present experiment activation of opioid receptors in the VTA does not appear to mimic the discriminative stimulus effects of systemically administered heroin.
Positive_regulation (activation) of VTA associated with opioid receptor
16) Confidence 0.39 Published 1995 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7667374 Disease Relevance 0.44 Pain Relevance 0.54
A single injection of 2.5 mg/kg (i.p.) of fluoxetine significantly increased the number of spontaneously active SNC and VTA DA neurons.
Positive_regulation (increased) of VTA in DA neurons associated with ventral tegmentum, dopamine and fluoxetine
17) Confidence 0.39 Published 2007 Journal Synapse Section Abstract Doc Link 17117425 Disease Relevance 0 Pain Relevance 1.19
The repeated administration (one injection per day for 21 days) of all of the SSRIs produced a significant increase in the number of spontaneously active VTA DA neurons.
Positive_regulation (increase) of VTA in DA neurons associated with ventral tegmentum, dopamine and ssri
18) Confidence 0.39 Published 2007 Journal Synapse Section Abstract Doc Link 17117425 Disease Relevance 0 Pain Relevance 1.22
In contrast, a single injection of either 1 mg/kg (i.p.) of paroxetine or 5 mg/kg of fluoxetine significantly increased the number of spontaneously active VTA DA neurons.
Positive_regulation (increased) of VTA in DA neurons associated with ventral tegmentum, dopamine and fluoxetine
19) Confidence 0.39 Published 2007 Journal Synapse Section Abstract Doc Link 17117425 Disease Relevance 0 Pain Relevance 1.22
Induction of deltaFosB in the VTA occurs after psychostimulant treatment only: it is seen with both chronic cocaine and amphetamine, but not with chronic opiates or stress.
Positive_regulation (Induction) of VTA associated with stress, ventral tegmentum, opiate and cocaine
20) Confidence 0.39 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15926929 Disease Relevance 0.09 Pain Relevance 0.98

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