INT317768

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nfe2l2, Acly) nucleus (Nfe2l2, Acly) plasma membrane (Nfe2l2, Acly)
mitochondrion (Acly) lyase activity (Acly) intracellular (Acly)
Nfe2l2 (Mus musculus)
Acly (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 8 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 75.00 Quite High
Toxicity 14 61.32 Quite High
Hepatotoxicity 10 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, we show here for the first time, that the enzyme ATP-citrate lyase, responsible for acetyl-CoA production, is negatively regulated by Nrf2.
Nrf2 Regulation (regulated) of ATP-citrate lyase
1) Confidence 0.38 Published 2010 Journal Journal of Proteomics Section Abstract Doc Link PMC2891861 Disease Relevance 0.20 Pain Relevance 0
ATP-citrate lyase is negatively regulated by Nrf2 in mice
Nrf2 Regulation (regulated) of ATP-citrate lyase
2) Confidence 0.17 Published 2010 Journal Journal of Proteomics Section Body Doc Link PMC2891861 Disease Relevance 0.06 Pain Relevance 0

General Comments

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