INT317791

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.31
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HDAC2) nucleus (HDAC2) enzyme binding (HDAC2)
transcription factor binding (HDAC2) cytoplasm (HDAC2)
Anatomy Link Frequency
internal 1
HDAC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 30 98.58 Very High Very High Very High
cytokine 7 97.50 Very High Very High Very High
rheumatoid arthritis 74 96.64 Very High Very High Very High
Osteoarthritis 36 96.36 Very High Very High Very High
dexamethasone 1 94.96 High High
Inflammatory mediators 2 66.72 Quite High
corticosteroid 6 63.88 Quite High
Arthritis 5 41.80 Quite Low
cINOD 5 20.60 Low Low
agonist 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 53 99.12 Very High Very High Very High
INFLAMMATION 36 98.58 Very High Very High Very High
Rheumatoid Arthritis 74 96.64 Very High Very High Very High
Frailty 38 96.36 Very High Very High Very High
Repression 3 93.20 High High
Shock 1 80.40 Quite High
Disease 13 75.20 Quite High
Cancer 8 50.00 Quite Low
Necrosis 4 50.00 Quite Low
Arthritis 5 41.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of HAT activity is elevated in patients with asthma, and HDAC activity is reduced in bronchial biopsies, which may contribute to local proinflammatory cytokine production.20 Glucocorticoids switch off inflammatory genes in those with asthma by directly inhibiting HAT activity and by recruiting HDAC2 to activate nuclear factor ?
Localization (recruiting) of HDAC2 associated with asthma, inflammation and cytokine
1) Confidence 0.50 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892049 Disease Relevance 0.69 Pain Relevance 0.25
Because HDAC1 and HDAC2 are localized mainly at the cell nuclei, we compared the nuclear protein levels of HDACs between RA and OA, with lamin A as an internal control, and showed a significant increase of HDAC1 protein in RA cells.
Localization (localized) of HDAC2 in internal associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.62 Pain Relevance 0.74

General Comments

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