INT317792

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.82
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HAT1) nucleolus (HAT1) nucleus (HAT1)
transferase activity, transferring acyl groups (HAT1) cytoplasm (HAT1)
HAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 74 99.84 Very High Very High Very High
Osteoarthritis 36 99.68 Very High Very High Very High
Inflammation 30 99.20 Very High Very High Very High
cytokine 7 98.12 Very High Very High Very High
dexamethasone 1 93.04 High High
corticosteroid 6 65.12 Quite High
cINOD 5 21.84 Low Low
agonist 15 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 74 99.84 Very High Very High Very High
Asthma 53 99.74 Very High Very High Very High
Frailty 38 99.68 Very High Very High Very High
INFLAMMATION 36 99.20 Very High Very High Very High
Repression 3 91.28 High High
Shock 1 78.48 Quite High
Cancer 8 50.00 Quite Low
Necrosis 4 50.00 Quite Low
Disease 13 32.72 Quite Low
Occupational Lung Diseases 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of HAT activity is elevated in patients with asthma, and HDAC activity is reduced in bronchial biopsies, which may contribute to local proinflammatory cytokine production.20 Glucocorticoids switch off inflammatory genes in those with asthma by directly inhibiting HAT activity and by recruiting HDAC2 to activate nuclear factor ?
Negative_regulation (inhibiting) of HAT Binding (activity) of associated with asthma, inflammation and cytokine
1) Confidence 0.07 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892049 Disease Relevance 0.69 Pain Relevance 0.25
Measurement of HAT activity in RA, OA and normal synovial tissues
Negative_regulation (Measurement) of HAT Binding (activity) of associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.13 Pain Relevance 0.56

General Comments

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