INT317823

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 3.33
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mvk) mRNA binding (Mvk) peroxisome (Mvk)
kinase activity (Mvk) cytoplasm (Mvk)
Mvk (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 4 95.80 Very High Very High Very High
Inflammation 47 91.04 High High
Etanercept 1 78.20 Quite High
corticosteroid 3 72.80 Quite High
Arthritis 4 69.20 Quite High
headache 1 67.44 Quite High
Angina 1 16.96 Low Low
ischemia 10 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
anakinra 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 58 99.24 Very High Very High Very High
Abdominal Pain 4 95.80 Very High Very High Very High
Splenomegaly 1 95.00 High High
Lymphadenopathy 2 94.44 High High
Fever 19 93.76 High High
Syndrome 9 92.20 High High
INFLAMMATION 46 91.04 High High
Hypergammaglobulinemia 1 79.60 Quite High
Necrosis 2 77.00 Quite High
Cancer 2 76.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MKD is due to mutations in the MVK gene, resulting in decreased activities of mevalonate kinase (MK; EC 2.7.1.36), the first enzyme following the highly regulated 3-hydroxy-3-methylgluaryl (HMG-CoA reductase) in the isoprenoid biosynthesis pathway (Houten et al 2003a; Waterham 2006).
Positive_regulation (resulting) of Negative_regulation (decreased) of mevalonate kinase associated with mevalonate kinase deficiency
1) Confidence 0.30 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 1.09 Pain Relevance 0.17
This autosomal recessive disorder is caused by homozygous mutations in the gene (MVK) resulting in decreased mevalonate kinase activity, with effects on the isoprenoid pathway of cholesterol biosynthesis [19•].
Positive_regulation (resulting) of Negative_regulation (decreased) of mevalonate kinase
2) Confidence 0.17 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 2.23 Pain Relevance 0.46

General Comments

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