INT317832

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.89
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mefv) nucleus (Mefv) intracellular (Mefv)
cytoplasm (Mefv)
Mefv (Mus musculus)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 86 99.60 Very High Very High Very High
Arthritis 6 86.16 High High
Angina 2 82.32 Quite High
abdominal pain 6 80.68 Quite High
anakinra 10 66.32 Quite High
Etanercept 2 47.00 Quite Low
corticosteroid 6 41.60 Quite Low
fibrosis 4 34.00 Quite Low
ischemia 20 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 84 99.60 Very High Very High Very High
Disease 36 99.44 Very High Very High Very High
Fever 28 96.52 Very High Very High Very High
Amyloidosis 8 95.88 Very High Very High Very High
Acne 4 91.88 High High
Ulcers 2 91.20 High High
Arthritis 6 90.48 High High
Renal Disease 4 88.84 High High
Pyoderma Gangrenosum 2 87.04 High High
Angina 2 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations in the proline-serine-threonine phosphatase interacting protein-1 are responsible for disease and are believed to affect interactions with the pyrin protein, resulting in IL-1-mediated inflammation [19•].
pyrin protein Binding (interactions) of IL-1 associated with inflammation and disease
1) Confidence 0.03 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.90 Pain Relevance 0.44
Pyrin has some structural similarities to the NLR proteins and may interact with NLR inflammasomes or form its own inflammasome, resulting in dysregulated caspase-1 activation and IL-1?
Pyrin Binding (resulting) of IL-1
2) Confidence 0.03 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.99 Pain Relevance 0.26

General Comments

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