INT317874

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 18
Disease Relevance 6.72
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Angptl4) extracellular space (Angptl4) extracellular region (Angptl4)
proteinaceous extracellular matrix (Angptl4)
Anatomy Link Frequency
F19 6
SW480 1
fat 1
liver 1
Angptl4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 155 96.48 Very High Very High Very High
Inflammation 108 74.40 Quite High
cytokine 9 45.16 Quite Low
Inflammatory mediators 1 29.52 Quite Low
isoflurane 18 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 16 98.20 Very High Very High Very High
Sprains And Strains 153 96.52 Very High Very High Very High
Obesity 231 96.28 Very High Very High Very High
Aids-related Complex 142 94.88 High High
Death 6 93.12 High High
Metabolic Syndrome 15 91.84 High High
Cancer 31 91.52 High High
Colon Cancer 15 87.92 High High
Weight Gain 62 82.44 Quite High
Disease 37 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the anaerobic commensal B. thetaiotaomicron, is unable to induce ANGPTL4 which is in line with the reported inability of whole flora to increase ANGPTL4 expression [6].
Neg (unable) Positive_regulation (induce) of ANGPTL4
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.41 Pain Relevance 0
Monocolonizing GF NMRI mice with F19 for two weeks resulted in increased circulating ANGPTL4 protein compared to non-infected GF mice.
Positive_regulation (increased) of ANGPTL4 protein in F19
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.06 Pain Relevance 0
The Lactobacillus rhamnosus GG (LGG) was also able to upregulate ANGPTL4 mRNA (data not shown).
Positive_regulation (upregulate) of ANGPTL4 mRNA
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.13 Pain Relevance 0.07
This implies that one route by which F19 signals for ANGPTL4 increase is via the PPARs, which have crucial roles in energy homeostasis and adipogenesis (reviewed in [19]).
Positive_regulation (increase) of ANGPTL4 in F19
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.06 Pain Relevance 0
In addition, the signature increase in triglycerides was also seen, an observation compatible with an LPL inhibition caused by the increase in ANGPTL4 serum levels.
Positive_regulation (increase) of ANGPTL4
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.07 Pain Relevance 0
Whereas F19 and BB12 generated an upregulation of ANGPTL4 mRNA, the commensal B.theta, was unable to stimulate expression in this cell line.
Positive_regulation (upregulation) of ANGPTL4 mRNA in F19
6) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.20 Pain Relevance 0.08
were abrogated by siRNA, induction of ANGPTL4 by F19 was considerably compromised.
Positive_regulation (induction) of ANGPTL4 in F19
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.12 Pain Relevance 0
In contrast, the anaerobic commensal B. thetaiotaomicron, is unable to induce ANGPTL4 which is in line with the reported inability of whole flora to increase ANGPTL4 expression [6].
Neg (unable) Positive_regulation (increase) of ANGPTL4
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.40 Pain Relevance 0
, all downregulated, and upregulated genes angiopoietin-related protein 4 (ANGPTL4), CCL6 and NR1D1.
Positive_regulation (upregulated) of angiopoietin-related protein 4
9) Confidence 0.49 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.35 Pain Relevance 0.03
To elucidate the mechanism of ANGPTL4 gene induction, distinct components of the bacteria-cell interaction were studied.
Positive_regulation (induction) of ANGPTL4 gene
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.06 Pain Relevance 0.03
The issue of cell line exclusivity was addressed by quantifying ANGPTL4 mRNA after F19 stimulation in the colonic cell lines LoVo, HT29 and SW480, which all showed a similar upregulation of ANGPTL4 mRNA to that of HCT116 (Figure 2E).
Positive_regulation (upregulation) of ANGPTL4 mRNA in SW480
11) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.06 Pain Relevance 0.05
Circulating ANGPTL4 levels were upregulated in the F19 supplemented group (Figure 1D).
Positive_regulation (upregulated) of ANGPTL4 in F19
12) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.30 Pain Relevance 0.10
To this end, we now confirm a clear difference in stored adiposity between F19 and control mice on a high fat diet, and furthermore observe an elevation of serum triglycerides possibly as a consequence of the increase in circulating ANGPTL4.
Positive_regulation (increase) of ANGPTL4 in fat
13) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.42 Pain Relevance 0
Elevated ANGPTL4 levels were further confirmed at the protein level in extracts from cells stimulated for 6 h with a subsequent 18 h accumulation period (Figure 2D).
Positive_regulation (Elevated) of ANGPTL4
14) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.07 Pain Relevance 0.07
, all downregulated, and upregulated genes angiopoietin-related protein 4 (ANGPTL4), CCL6 and NR1D1.
Positive_regulation (upregulated) of ANGPTL4
15) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.36 Pain Relevance 0.03
did not influence the ability of F19 to upregulate ANGPTL4 (Figure 4B).
Positive_regulation (upregulate) of ANGPTL4 in F19
16) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0 Pain Relevance 0
Indeed, similar effects on lipoproteins have been seen in ANGPTL4 transgenic mice, strengthening the probability that increased triglycerides is a direct function of increased levels of circulating ANGPTL4 [15].
Positive_regulation (increased) of ANGPTL4 associated with targeted disruption
17) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.42 Pain Relevance 0
Gut bacteria also suppress the expression and release of fasting induced adipose factor (Fiaf) from small intestine, resulting in increased activity of lipoprotein-lipase (LPL) in adipocytes and enhanced storage of liver-derived triglycerides [12], [13].
Positive_regulation (induced) of adipose factor in liver associated with obesity
18) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 1.22 Pain Relevance 0.16

General Comments

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