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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.98
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Dusp1) nucleoplasm (Dusp1) nucleus (Dusp1)
cell cycle (Dusp1)
Anatomy Link Frequency
lung 2
Dusp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 91 100.00 Very High Very High Very High
Lasting pain 23 99.20 Very High Very High Very High
Inflammation 27 96.40 Very High Very High Very High
cytokine 3 95.88 Very High Very High Very High
chemokine 6 77.48 Quite High
depression 4 62.28 Quite High
Opioid 6 27.96 Quite Low
Chronic low back pain 3 24.16 Low Low
Pain threshold 9 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 119 100.00 Very High Very High Very High
Aids-related Complex 71 99.66 Very High Very High Very High
INFLAMMATION 26 96.40 Very High Very High Very High
Alzheimer's Dementia 1 90.36 High High
Acute-phase Reaction 2 89.48 High High
Immune System Diseases 2 88.08 High High
Disease 11 86.20 High High
Sprains And Strains 54 75.60 Quite High
Depression 5 62.28 Quite High
Cancer 15 53.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The top network in the B6 GMA-SS-exposed lung consisted primarily of decreased gene expression for dual specificity phosphatase 1 (DUSP1), a downregulator of MAPK signaling, transcriptional regulators EGR1, FOS, FOSB, and pro-inflammatory cytokine IL1?
Regulation (consisted) of Gene_expression (expression) of DUSP1 in lung associated with inflammation, aids-related complex and cytokine
1) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.11 Pain Relevance 0.17
There was, however, an interaction between pain status and the Met allele (N2-component of C4), indicating that the effect of the COMT Met allele on the pain ERP was moderated by the presence of chronic pain complaints.
Regulation (moderated) of Gene_expression (effect) of ERP associated with pain and lasting pain
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 1.87 Pain Relevance 1.76

General Comments

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