INT317913

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Context Info
Confidence 0.64
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.19
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SHANK3) cytoplasm (SHANK3)
Anatomy Link Frequency
cerebral cortex 1
cerebellum 1
SHANK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 3 99.68 Very High Very High Very High
Central nervous system 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Toxicity (including Many Sub-types) 6 91.76 High High
Microcephaly 24 91.08 High High
Congenital Anomalies 66 90.32 High High
Intrauterine Growth Retardation 3 86.76 High High
Autism 9 85.72 High High
Muscle Hypotonia 6 84.28 Quite High
Syndrome 15 83.08 Quite High
Birth Weight 9 72.20 Quite High
Metastasis 3 58.36 Quite High
Hirsutism 6 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven genes reside in the duplicated area, which contains SHANK3, ACR, RABL2B, MAPK8IP2 (mitogen-activated protein kinase 8 interacting) and ARSA (arylsulfatase A, isoform b).
Gene_expression (contains) of SHANK3
1) Confidence 0.64 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.63 Pain Relevance 0.03
SHANK3 is a good candidate gene, as it is preferentially expressed in the cerebral cortex and cerebellum, and encodes a scaffolding protein involved in the postsynaptic density of excitatory synapses.
Gene_expression (expressed) of SHANK3 in cerebral cortex associated with cerebral cortex
2) Confidence 0.64 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.78 Pain Relevance 0.05
SHANK3 is a good candidate gene, as it is preferentially expressed in the cerebral cortex and cerebellum, and encodes a scaffolding protein involved in the postsynaptic density of excitatory synapses.
Gene_expression (expressed) of SHANK3 in cerebellum associated with cerebral cortex
3) Confidence 0.22 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.78 Pain Relevance 0.05

General Comments

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