INT317918

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.43
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MAPK8IP2) protein complex (MAPK8IP2) cytoplasm (MAPK8IP2)
Anatomy Link Frequency
neuroendocrine cells 1
neural 1
MAPK8IP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 10 65.76 Quite High
cerebral cortex 1 56.72 Quite High
nMDA receptor 50 37.44 Quite Low
Glutamate 42 31.92 Quite Low
amygdala 116 5.00 Very Low Very Low Very Low
long-term potentiation 28 5.00 Very Low Very Low Very Low
withdrawal 18 5.00 Very Low Very Low Very Low
Pyramidal cell 16 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
medulla 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microcephaly 8 91.08 High High
Congenital Anomalies 30 90.32 High High
Intrauterine Growth Retardation 1 86.76 High High
Autism 631 76.56 Quite High
Birth Weight 3 72.20 Quite High
Adhesions 3 71.00 Quite High
Intellectual Impairment 54 54.48 Quite High
Syndrome 47 51.28 Quite High
Hirsutism 2 49.76 Quite Low
Toxicity 12 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven genes reside in the duplicated area, which contains SHANK3, ACR, RABL2B, MAPK8IP2 (mitogen-activated protein kinase 8 interacting) and ARSA (arylsulfatase A, isoform b).
Gene_expression (contains) of MAPK8IP2
1) Confidence 0.59 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.68 Pain Relevance 0.03
IB2 (for Islet Brain-2) is a the protein expressed in neural and neuroendocrine cells throughout the brain (Negri et al., 2000) and its disruption has been associated with reduced AMPA-mediated transmission and enhanced NMDA-mediated transmission in the cerebellum (Giza et al., 2010).
Gene_expression (expressed) of IB2 in neuroendocrine cells
2) Confidence 0.33 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.37 Pain Relevance 0.03
IB2 (for Islet Brain-2) is a the protein expressed in neural and neuroendocrine cells throughout the brain (Negri et al., 2000) and its disruption has been associated with reduced AMPA-mediated transmission and enhanced NMDA-mediated transmission in the cerebellum (Giza et al., 2010).
Gene_expression (expressed) of IB2 in neural
3) Confidence 0.11 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.37 Pain Relevance 0.03

General Comments

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